Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none responses, yet TLR activation by diverse microbes induces anything...

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Bibliographic Details
Main Authors: Sarah Louise Latty, Jiro Sakai, Lee Hopkins, Brett Verstak, Teresa Paramo, Nils A Berglund, Eugenia Cammarota, Pietro Cicuta, Nicholas J Gay, Peter J Bond, David Klenerman, Clare E Bryant
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
Toll-like receptors
single molecule fluorescence
MyD88
TLR signalling
Online Access:https://elifesciences.org/articles/31377

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