Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.857812/full |
| _version_ | 1811233994356817920 |
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| author | Lidawani Lambuk Suhana Ahmad Muhammad Zulfiqah Sadikan Nor Asyikin Nordin Ramlah Kadir Nurul Alimah Abdul Nasir Xin Chen Jennifer Boer Magdalena Plebanski Rohimah Mohamud |
| author_facet | Lidawani Lambuk Suhana Ahmad Muhammad Zulfiqah Sadikan Nor Asyikin Nordin Ramlah Kadir Nurul Alimah Abdul Nasir Xin Chen Jennifer Boer Magdalena Plebanski Rohimah Mohamud |
| author_sort | Lidawani Lambuk |
| collection | DOAJ |
| description | Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma. |
| first_indexed | 2024-04-12T11:29:21Z |
| format | Article |
| id | doaj.art-ec08543aeba24f0e8d1a82544adcf63a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T11:29:21Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec08543aeba24f0e8d1a82544adcf63a2022-12-22T03:35:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.857812857812Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for GlaucomaLidawani Lambuk0Suhana Ahmad1Muhammad Zulfiqah Sadikan2Nor Asyikin Nordin3Ramlah Kadir4Nurul Alimah Abdul Nasir5Xin Chen6Jennifer Boer7Magdalena Plebanski8Rohimah Mohamud9Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaCentre for Neuroscience Research (NeuRon), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaCentre for Neuroscience Research (NeuRon), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, MalaysiaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, ChinaSchool of Health and Biomedical Sciences, Royal Melbourne Institute Technology (RMIT) University, Bundoora, VIC, AustraliaSchool of Health and Biomedical Sciences, Royal Melbourne Institute Technology (RMIT) University, Bundoora, VIC, AustraliaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaGlaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma.https://www.frontiersin.org/articles/10.3389/fimmu.2022.857812/fulltumour necrosis factorTNFR1TNFR2glaucomaretinal ganglion cellsneurodegeneration |
| spellingShingle | Lidawani Lambuk Suhana Ahmad Muhammad Zulfiqah Sadikan Nor Asyikin Nordin Ramlah Kadir Nurul Alimah Abdul Nasir Xin Chen Jennifer Boer Magdalena Plebanski Rohimah Mohamud Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma Frontiers in Immunology tumour necrosis factor TNFR1 TNFR2 glaucoma retinal ganglion cells neurodegeneration |
| title | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
| title_full | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
| title_fullStr | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
| title_full_unstemmed | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
| title_short | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
| title_sort | targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma |
| topic | tumour necrosis factor TNFR1 TNFR2 glaucoma retinal ganglion cells neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.857812/full |
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