Role of tumor microenvironment in cancer progression and therapeutic strategy
Abstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various antica...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5698 |
| _version_ | 1827932398272118784 |
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| author | Qingjing Wang Xueting Shao Yuxuan Zhang Miaojin Zhu Frederick X. C. Wang Jianjian Mu Jiaxuan Li Hangping Yao Keda Chen |
| author_facet | Qingjing Wang Xueting Shao Yuxuan Zhang Miaojin Zhu Frederick X. C. Wang Jianjian Mu Jiaxuan Li Hangping Yao Keda Chen |
| author_sort | Qingjing Wang |
| collection | DOAJ |
| description | Abstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various anticancer therapies, including immunotherapies. Cancer immunotherapy can recognize and kill cancer cells by regulating the body's immune system. It has achieved good therapeutic effects in various solid tumors and hematological malignancies. Recently, blocking of programmed death‐1 (PD‐1), programmed death‐1 ligand‐1 (PD‐L1), and programmed death Ligand‐2 (PD‐L2), the construction of antigen chimeric T cells (CAR‐T) and tumor vaccines have become popular immunotherapies Tumorigenesis, progression, and metastasis are closely related to TME. Therefore, we review the characteristics of various cells and molecules in the TME, the interaction between PD‐1 and TME, and promising cancer immunotherapy therapeutics. |
| first_indexed | 2024-03-13T07:08:07Z |
| format | Article |
| id | doaj.art-ec09f57e054642f390d5f16ddfd46f5e |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-13T07:08:07Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-ec09f57e054642f390d5f16ddfd46f5e2023-06-06T07:30:47ZengWileyCancer Medicine2045-76342023-05-011210111491116510.1002/cam4.5698Role of tumor microenvironment in cancer progression and therapeutic strategyQingjing Wang0Xueting Shao1Yuxuan Zhang2Miaojin Zhu3Frederick X. C. Wang4Jianjian Mu5Jiaxuan Li6Hangping Yao7Keda Chen8Shulan International Medical College Zhejiang Shuren University Hangzhou ChinaInstitute of Pharmaceutical Biotechnology & Research Center for Clinical Pharmacy, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou ChinaShulan International Medical College Zhejiang Shuren University Hangzhou ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou ChinaThe EnMed Program at Houston Methodist Hospital Texas A&M University College of Medicine and College of Engineering Houston Texas USAShulan International Medical College Zhejiang Shuren University Hangzhou ChinaShulan International Medical College Zhejiang Shuren University Hangzhou ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou ChinaShulan International Medical College Zhejiang Shuren University Hangzhou ChinaAbstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various anticancer therapies, including immunotherapies. Cancer immunotherapy can recognize and kill cancer cells by regulating the body's immune system. It has achieved good therapeutic effects in various solid tumors and hematological malignancies. Recently, blocking of programmed death‐1 (PD‐1), programmed death‐1 ligand‐1 (PD‐L1), and programmed death Ligand‐2 (PD‐L2), the construction of antigen chimeric T cells (CAR‐T) and tumor vaccines have become popular immunotherapies Tumorigenesis, progression, and metastasis are closely related to TME. Therefore, we review the characteristics of various cells and molecules in the TME, the interaction between PD‐1 and TME, and promising cancer immunotherapy therapeutics.https://doi.org/10.1002/cam4.5698cancer immunotherapycancer progressionPD‐1PD‐L1tumor microenvironment |
| spellingShingle | Qingjing Wang Xueting Shao Yuxuan Zhang Miaojin Zhu Frederick X. C. Wang Jianjian Mu Jiaxuan Li Hangping Yao Keda Chen Role of tumor microenvironment in cancer progression and therapeutic strategy Cancer Medicine cancer immunotherapy cancer progression PD‐1 PD‐L1 tumor microenvironment |
| title | Role of tumor microenvironment in cancer progression and therapeutic strategy |
| title_full | Role of tumor microenvironment in cancer progression and therapeutic strategy |
| title_fullStr | Role of tumor microenvironment in cancer progression and therapeutic strategy |
| title_full_unstemmed | Role of tumor microenvironment in cancer progression and therapeutic strategy |
| title_short | Role of tumor microenvironment in cancer progression and therapeutic strategy |
| title_sort | role of tumor microenvironment in cancer progression and therapeutic strategy |
| topic | cancer immunotherapy cancer progression PD‐1 PD‐L1 tumor microenvironment |
| url | https://doi.org/10.1002/cam4.5698 |
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