A Review of Ophthalmic Complications in Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions caused by various polygenic and environmental factors. Clinical manifestations of IBD primarily occur in the gastrointestinal tract, but many patients are affected by...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7457 |
| _version_ | 1797457098324312064 |
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| author | Wiktoria Pytrus Katarzyna Akutko Tomasz Pytrus Anna Turno-Kręcicka |
| author_facet | Wiktoria Pytrus Katarzyna Akutko Tomasz Pytrus Anna Turno-Kręcicka |
| author_sort | Wiktoria Pytrus |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions caused by various polygenic and environmental factors. Clinical manifestations of IBD primarily occur in the gastrointestinal tract, but many patients are affected by extraintestinal complications, including eye diseases. Ocular disorders are the third most common extraintestinal manifestation (EIM), following musculoskeletal and mucocutaneous involvement. Episcleritis, frequently occurring in IBD patients, may be associated with exacerbation of the intestinal disease. Uveitis does not correlate with IBD activity but may be related to the presence of other EIMs, particularly erythema nodosum and peripheral arthritis. Early detection and specific therapy of ocular manifestations of IBD are fundamental to avoiding sight-threatening complications. Therefore, ophthalmic evaluation should be performed in all IBD patients. Systemic corticosteroids or immunosuppressants may be inevitable in severe cases to control ocular inflammation. Persistent and relapsing conditions usually respond well to TNF-α-inhibitors. Interdisciplinary cooperation between gastroenterologists and ophthalmologists is fundamental in initiating the appropriate treatment for patients. |
| first_indexed | 2024-03-09T16:16:20Z |
| format | Article |
| id | doaj.art-ec0b93e3ce874344bab7f12e7bed3a6e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:16:20Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ec0b93e3ce874344bab7f12e7bed3a6e2023-11-24T15:45:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124745710.3390/jcm11247457A Review of Ophthalmic Complications in Inflammatory Bowel DiseasesWiktoria Pytrus0Katarzyna Akutko1Tomasz Pytrus2Anna Turno-Kręcicka3Ophthalmonology Clinical Centre SPEKTRUM, 53-334 Wroclaw, Poland2nd Department and Clinic of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, Poland2nd Department and Clinic of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandClinical Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandInflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions caused by various polygenic and environmental factors. Clinical manifestations of IBD primarily occur in the gastrointestinal tract, but many patients are affected by extraintestinal complications, including eye diseases. Ocular disorders are the third most common extraintestinal manifestation (EIM), following musculoskeletal and mucocutaneous involvement. Episcleritis, frequently occurring in IBD patients, may be associated with exacerbation of the intestinal disease. Uveitis does not correlate with IBD activity but may be related to the presence of other EIMs, particularly erythema nodosum and peripheral arthritis. Early detection and specific therapy of ocular manifestations of IBD are fundamental to avoiding sight-threatening complications. Therefore, ophthalmic evaluation should be performed in all IBD patients. Systemic corticosteroids or immunosuppressants may be inevitable in severe cases to control ocular inflammation. Persistent and relapsing conditions usually respond well to TNF-α-inhibitors. Interdisciplinary cooperation between gastroenterologists and ophthalmologists is fundamental in initiating the appropriate treatment for patients.https://www.mdpi.com/2077-0383/11/24/7457inflammatory bowel diseaseextraintestinal manifestationocular involvement |
| spellingShingle | Wiktoria Pytrus Katarzyna Akutko Tomasz Pytrus Anna Turno-Kręcicka A Review of Ophthalmic Complications in Inflammatory Bowel Diseases Journal of Clinical Medicine inflammatory bowel disease extraintestinal manifestation ocular involvement |
| title | A Review of Ophthalmic Complications in Inflammatory Bowel Diseases |
| title_full | A Review of Ophthalmic Complications in Inflammatory Bowel Diseases |
| title_fullStr | A Review of Ophthalmic Complications in Inflammatory Bowel Diseases |
| title_full_unstemmed | A Review of Ophthalmic Complications in Inflammatory Bowel Diseases |
| title_short | A Review of Ophthalmic Complications in Inflammatory Bowel Diseases |
| title_sort | review of ophthalmic complications in inflammatory bowel diseases |
| topic | inflammatory bowel disease extraintestinal manifestation ocular involvement |
| url | https://www.mdpi.com/2077-0383/11/24/7457 |
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