Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis.

Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis.

<h4>Background</h4>We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, and 44% remained unpublished at a median of 12 years follow-up. We aimed to assess a decade later (1) whether rates of completion and p...

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Main Authors: Benjamin Speich, Dmitry Gryaznov, Jason W Busse, Viktoria L Gloy, Szimonetta Lohner, Katharina Klatte, Ala Taji Heravi, Nilabh Ghosh, Hopin Lee, Anita Mansouri, Ioana R Marian, Ramon Saccilotto, Edris Nury, Benjamin Kasenda, Elena Ojeda-Ruiz, Stefan Schandelmaier, Yuki Tomonaga, Alain Amstutz, Christiane Pauli-Magnus, Karin Bischoff, Katharina Wollmann, Laura Rehner, Joerg J Meerpohl, Alain Nordmann, Jacqueline Wong, Ngai Chow, Patrick Jiho Hong, Kimberly Mc Cord-De Iaco, Sirintip Sricharoenchai, Arnav Agarwal, Matthias Schwenkglenks, Lars G Hemkens, Erik von Elm, Bethan Copsey, Alexandra N Griessbach, Christof Schönenberger, Dominik Mertz, Anette Blümle, Belinda von Niederhäusern, Sally Hopewell, Ayodele Odutayo, Matthias Briel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003980

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