The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial
Background: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption. Objective: To assess the effect of adm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2017-01-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/297 |
| _version_ | 1818460251131740160 |
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| author | M Bayat A Garajei E Afshari Pour M Hasheminasab Y Ghorbani MH Kalantar Motamedi N Bahrami |
| author_facet | M Bayat A Garajei E Afshari Pour M Hasheminasab Y Ghorbani MH Kalantar Motamedi N Bahrami |
| author_sort | M Bayat |
| collection | DOAJ |
| description | Background: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption.
Objective: To assess the effect of administration of biphosphonates on bone resorption.
Methods: 20 patients with bony defects who were candidates for free autogenous grafts were randomized into “pamidronate” and “control” groups. Bone segments were soaked in either pamidronate solution or normal saline and were inserted into the area of the surgery. Bone densities were measured post-surgery and in 6-month follow-up. Data were obtained via Digora software and analyzed.
Results: The mean±SD bone density in pamidronate group changed from 93.4±14.6 to 93.6±17.5 (p<0.05); in the control group the density decreased from 89.7±13.2 to 78.9±11.4 (p<0.05). The mean difference of bone density in anterior areas of the jaws showed higher DXA in comparison to posterior regions (p=0.002).
Conclusion: Locally administered pamidronate affects reduction in bone resorption. |
| first_indexed | 2024-12-14T23:27:16Z |
| format | Article |
| id | doaj.art-ec0edca657084a7fade654ad26575b90 |
| institution | Directory Open Access Journal |
| issn | 2008-6482 2008-6490 |
| language | English |
| last_indexed | 2024-12-14T23:27:16Z |
| publishDate | 2017-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-ec0edca657084a7fade654ad26575b902022-12-21T22:43:46ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64822008-64902017-01-0181232The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical TrialM Bayat0A Garajei1E Afshari Pour2M Hasheminasab3Y Ghorbani4MH Kalantar Motamedi5N Bahrami6Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, IranCraniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, IranOral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranOral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranDepartment of Physiology, Islamic Azad University, Tehran, IranOral and Maxillofacial Surgery, Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranCraniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, IranBackground: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption. Objective: To assess the effect of administration of biphosphonates on bone resorption. Methods: 20 patients with bony defects who were candidates for free autogenous grafts were randomized into “pamidronate” and “control” groups. Bone segments were soaked in either pamidronate solution or normal saline and were inserted into the area of the surgery. Bone densities were measured post-surgery and in 6-month follow-up. Data were obtained via Digora software and analyzed. Results: The mean±SD bone density in pamidronate group changed from 93.4±14.6 to 93.6±17.5 (p<0.05); in the control group the density decreased from 89.7±13.2 to 78.9±11.4 (p<0.05). The mean difference of bone density in anterior areas of the jaws showed higher DXA in comparison to posterior regions (p=0.002). Conclusion: Locally administered pamidronate affects reduction in bone resorption.http://www.ijotm.com/ojs/index.php/IJOTM/article/view/297Bone transplantationPamidronate [supplementary concept]Reconstructive surgical proceduresOral surgical procedures |
| spellingShingle | M Bayat A Garajei E Afshari Pour M Hasheminasab Y Ghorbani MH Kalantar Motamedi N Bahrami The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial International Journal of Organ Transplantation Medicine Bone transplantation Pamidronate [supplementary concept] Reconstructive surgical procedures Oral surgical procedures |
| title | The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial |
| title_full | The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial |
| title_fullStr | The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial |
| title_full_unstemmed | The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial |
| title_short | The Effect of Locally Administered Pamidronate on Autogenous Bone Graft in Maxillofacial Reconstruction: A Randomized Clinical Trial |
| title_sort | effect of locally administered pamidronate on autogenous bone graft in maxillofacial reconstruction a randomized clinical trial |
| topic | Bone transplantation Pamidronate [supplementary concept] Reconstructive surgical procedures Oral surgical procedures |
| url | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/297 |
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