Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium
Tuberculosis is one of the world’s deadliest infectious disease with 1.5 millions deaths annually. It is imperative to discover novel compounds with potent activity against M. tuberculosis. In this study, susceptibilities of M. smegmatis to the octahedral ruthenium(II) polypyridyl complexes, 1 {[(bp...
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PeerJ Inc.
2017-04-01
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| Online Access: | https://peerj.com/articles/3252.pdf |
| _version_ | 1827607103497306112 |
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| author | Guojian Liao Zhengyuan Ye Yunlu Liu Bin Fu Chen Fu |
| author_facet | Guojian Liao Zhengyuan Ye Yunlu Liu Bin Fu Chen Fu |
| author_sort | Guojian Liao |
| collection | DOAJ |
| description | Tuberculosis is one of the world’s deadliest infectious disease with 1.5 millions deaths annually. It is imperative to discover novel compounds with potent activity against M. tuberculosis. In this study, susceptibilities of M. smegmatis to the octahedral ruthenium(II) polypyridyl complexes, 1 {[(bpy)3Ru] (PF6)2 (bpy = 2,2′-bipyridine)}, 2 {[(phen)2Ru(dppz)](PF6)2 (phen = 1,10-phenanthroline, dppz = dipyridophenazine)} and 3 {[(phen)3Ru](PF6)2} were measured by broth microdilution and reported as the MIC values. Toxicities of complex 3 to LO2 and hepG2 cell lines were also measured. Complex 2 inhibited the growth of M. smegmatis with MIC value of 2 µg/mL, while complex 3 was bactericidal with MIC value of 26 µg/mL. Furthermore, the bactericidal activity of complex 3 was dependent on reactive oxygen species production. Complex 3 showed no cytotoxicity against LO2 and hepG2 cell lines at concentration as high as 64 µg/mL, paving the way for further optimization and development as a novel antibacterial agent for the treatment of M. tuberculosis infection. |
| first_indexed | 2024-03-09T06:49:44Z |
| format | Article |
| id | doaj.art-ec0f79fcb0464a68bd58b651492699f5 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:49:44Z |
| publishDate | 2017-04-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
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| spelling | doaj.art-ec0f79fcb0464a68bd58b651492699f52023-12-03T10:29:37ZengPeerJ Inc.PeerJ2167-83592017-04-015e325210.7717/peerj.3252Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacteriumGuojian Liao0Zhengyuan Ye1Yunlu Liu2Bin Fu3Chen Fu4College of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaTuberculosis is one of the world’s deadliest infectious disease with 1.5 millions deaths annually. It is imperative to discover novel compounds with potent activity against M. tuberculosis. In this study, susceptibilities of M. smegmatis to the octahedral ruthenium(II) polypyridyl complexes, 1 {[(bpy)3Ru] (PF6)2 (bpy = 2,2′-bipyridine)}, 2 {[(phen)2Ru(dppz)](PF6)2 (phen = 1,10-phenanthroline, dppz = dipyridophenazine)} and 3 {[(phen)3Ru](PF6)2} were measured by broth microdilution and reported as the MIC values. Toxicities of complex 3 to LO2 and hepG2 cell lines were also measured. Complex 2 inhibited the growth of M. smegmatis with MIC value of 2 µg/mL, while complex 3 was bactericidal with MIC value of 26 µg/mL. Furthermore, the bactericidal activity of complex 3 was dependent on reactive oxygen species production. Complex 3 showed no cytotoxicity against LO2 and hepG2 cell lines at concentration as high as 64 µg/mL, paving the way for further optimization and development as a novel antibacterial agent for the treatment of M. tuberculosis infection.https://peerj.com/articles/3252.pdfRuthenium(II) complexesReactive oxygen speciesAntibacterial activity |
| spellingShingle | Guojian Liao Zhengyuan Ye Yunlu Liu Bin Fu Chen Fu Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium PeerJ Ruthenium(II) complexes Reactive oxygen species Antibacterial activity |
| title | Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium |
| title_full | Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium |
| title_fullStr | Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium |
| title_full_unstemmed | Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium |
| title_short | Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium |
| title_sort | octahedral ruthenium ii polypyridyl complexes as antimicrobial agents against mycobacterium |
| topic | Ruthenium(II) complexes Reactive oxygen species Antibacterial activity |
| url | https://peerj.com/articles/3252.pdf |
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