Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia
The incidence and mortality of sepsis in the intensive care unit (ICU) are extremely high. Thrombocytopenia, one of the most common laboratory abnormalities, is correlated with prognosis in sepsis. The pathophysiology of sepsis-associated thrombocytopenia (SAT) remains unclear and may be associated...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-10-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029620959467 |
| _version_ | 1817978511415050240 |
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| author | Xinghui Wu Yue Li Huasheng Tong |
| author_facet | Xinghui Wu Yue Li Huasheng Tong |
| author_sort | Xinghui Wu |
| collection | DOAJ |
| description | The incidence and mortality of sepsis in the intensive care unit (ICU) are extremely high. Thrombocytopenia, one of the most common laboratory abnormalities, is correlated with prognosis in sepsis. The pathophysiology of sepsis-associated thrombocytopenia (SAT) remains unclear and may be associated with several factors such as platelet activation due to vascular injury and pathogen, suppression of bone marrow, platelet-targeted antibodies and desialylation. This review summarized all these possible mechanisms in the 3 subtypes of SAT: increased platelet consumption, reduced platelet production and increased platelet destruction. Based on the clinically available platelet parameters, the evidence for identifying SAT subtypes and the recent progress in treatments according to these subtypes are proposed to provide new prospects for the management of SAT. |
| first_indexed | 2024-04-13T22:29:53Z |
| format | Article |
| id | doaj.art-ec0fdc6c7fb74eecb60afee306888d39 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-13T22:29:53Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-ec0fdc6c7fb74eecb60afee306888d392022-12-22T02:26:57ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232020-10-012610.1177/1076029620959467Research Advances in the Subtype of Sepsis-Associated ThrombocytopeniaXinghui Wu0Yue Li1Huasheng Tong2 The First School of Clinical Medicine, , Guangzhou, People’s Republic of China Department of Intensive Care Unit, , Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, People’s Republic of China Department of Intensive Care Unit, , Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, People’s Republic of ChinaThe incidence and mortality of sepsis in the intensive care unit (ICU) are extremely high. Thrombocytopenia, one of the most common laboratory abnormalities, is correlated with prognosis in sepsis. The pathophysiology of sepsis-associated thrombocytopenia (SAT) remains unclear and may be associated with several factors such as platelet activation due to vascular injury and pathogen, suppression of bone marrow, platelet-targeted antibodies and desialylation. This review summarized all these possible mechanisms in the 3 subtypes of SAT: increased platelet consumption, reduced platelet production and increased platelet destruction. Based on the clinically available platelet parameters, the evidence for identifying SAT subtypes and the recent progress in treatments according to these subtypes are proposed to provide new prospects for the management of SAT.https://doi.org/10.1177/1076029620959467 |
| spellingShingle | Xinghui Wu Yue Li Huasheng Tong Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia Clinical and Applied Thrombosis/Hemostasis |
| title | Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia |
| title_full | Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia |
| title_fullStr | Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia |
| title_full_unstemmed | Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia |
| title_short | Research Advances in the Subtype of Sepsis-Associated Thrombocytopenia |
| title_sort | research advances in the subtype of sepsis associated thrombocytopenia |
| url | https://doi.org/10.1177/1076029620959467 |
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