Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns
Background The trivalent oral polio vaccine (tOPV) produced by Bio Farma consists of three live, attenuated poliovirus serotypes (1, 2, and 3). The tOPV stimulates the formation of secretory IgA (sIgA) on the intestinal wall and lumen. The existence of sIgA is considered giving immunity in the intes...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2015-07-01
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| Series: | Paediatrica Indonesiana |
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| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/31 |
| _version_ | 1818179999949127680 |
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| author | Viramitha K. Rusmil Meita Dhamayanti Sunarjati Soedigdo Adi Imam Megantara |
| author_facet | Viramitha K. Rusmil Meita Dhamayanti Sunarjati Soedigdo Adi Imam Megantara |
| author_sort | Viramitha K. Rusmil |
| collection | DOAJ |
| description | Background The trivalent oral polio vaccine (tOPV) produced by Bio Farma consists of three live, attenuated poliovirus serotypes (1, 2, and 3). The tOPV stimulates the formation of secretory IgA (sIgA) on the intestinal wall and lumen. The existence of sIgA is considered giving immunity in the intestines, it could prevent the spread of viral replication and thus inhibit the transmission of the polio virus.
Objective To determine the differences in shedding after each of the first two tOPV immunizations in newborns.
Methods This one-way repeated measure study was conducted in newborns from three primary health centers in Bandung, West Java. After administering tOPV to newborns, we assessed the shedding of poliovirus in their stool specimens at 30 days after the first dose and 7 days after the second dose. Data was analyzed using McNemar test with 95% confidence intervals (CI) to differentiate the shedding of poliovirus after the first and second doses.
Results Of 150 children, 128 subjects completed the study. At 30 days after the first tOPV dose, 26 subjects (20.3%) were negative for shedding of poliovirus in stool specimens. Of the 102 subjects who had poliovirus isolated from their stools, the serotypes comprised of polio 1: 10.9%, polio 2: 14.8%, polio 3: 45.3%, polio 1 and 3: 3.1%, polio 2 and 3: 4.7%, and polio 1,2, and 3: 0.8%. At 7 days after the second tOPV dose, there was a significant increase in subjects negative for shedding of poliovirus (78 subjects; 60.9%). Statistical analysis revealed significantly decreased shedding of poliovirus in stool specimens between the first and second doses of tOPV (P<0.05 ).
Conclusion There is a significantly decreased number of subjects with shedding of poliovirus in stool specimens 7 days after the second tOPV dose than at 30 days after the first tOPV dose. |
| first_indexed | 2024-12-11T21:12:48Z |
| format | Article |
| id | doaj.art-ec1104887b804f8584462855cc920cf9 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-11T21:12:48Z |
| publishDate | 2015-07-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-ec1104887b804f8584462855cc920cf92022-12-22T00:50:41ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2015-07-015542192310.14238/pi55.4.2015.219-2319Poliovirus shedding after the first and second doses of trivalent polio vaccines in newbornsViramitha K. Rusmil0Meita Dhamayanti1Sunarjati Soedigdo Adi2Imam Megantara3Department of Child Health, Padjadjaran University Medical School/Dr. Hasan Sadikin General Hospital Bandung, Indonesia.meita_d@yahoo.comDepartment of Clinical Microbiology, Padjadjaran University Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaDepartment of Clinical Microbiology, Padjadjaran University Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java, IndonesiaBackground The trivalent oral polio vaccine (tOPV) produced by Bio Farma consists of three live, attenuated poliovirus serotypes (1, 2, and 3). The tOPV stimulates the formation of secretory IgA (sIgA) on the intestinal wall and lumen. The existence of sIgA is considered giving immunity in the intestines, it could prevent the spread of viral replication and thus inhibit the transmission of the polio virus. Objective To determine the differences in shedding after each of the first two tOPV immunizations in newborns. Methods This one-way repeated measure study was conducted in newborns from three primary health centers in Bandung, West Java. After administering tOPV to newborns, we assessed the shedding of poliovirus in their stool specimens at 30 days after the first dose and 7 days after the second dose. Data was analyzed using McNemar test with 95% confidence intervals (CI) to differentiate the shedding of poliovirus after the first and second doses. Results Of 150 children, 128 subjects completed the study. At 30 days after the first tOPV dose, 26 subjects (20.3%) were negative for shedding of poliovirus in stool specimens. Of the 102 subjects who had poliovirus isolated from their stools, the serotypes comprised of polio 1: 10.9%, polio 2: 14.8%, polio 3: 45.3%, polio 1 and 3: 3.1%, polio 2 and 3: 4.7%, and polio 1,2, and 3: 0.8%. At 7 days after the second tOPV dose, there was a significant increase in subjects negative for shedding of poliovirus (78 subjects; 60.9%). Statistical analysis revealed significantly decreased shedding of poliovirus in stool specimens between the first and second doses of tOPV (P<0.05 ). Conclusion There is a significantly decreased number of subjects with shedding of poliovirus in stool specimens 7 days after the second tOPV dose than at 30 days after the first tOPV dose.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/31tOPVnewbornsshedding of poliovirusstools |
| spellingShingle | Viramitha K. Rusmil Meita Dhamayanti Sunarjati Soedigdo Adi Imam Megantara Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns Paediatrica Indonesiana tOPV newborns shedding of poliovirus stools |
| title | Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| title_full | Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| title_fullStr | Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| title_full_unstemmed | Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| title_short | Poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| title_sort | poliovirus shedding after the first and second doses of trivalent polio vaccines in newborns |
| topic | tOPV newborns shedding of poliovirus stools |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/31 |
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