Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers
We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2018-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/9/17-1709_article |
| _version_ | 1818416896251265024 |
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| author | Önder Ergönül Şiran Keske Melis Gökçe Çeldir İlayda Arjen Kara Natalia Pshenichnaya Gulzhan Abuova Lucille Blumberg Mehmet Gönen |
| author_facet | Önder Ergönül Şiran Keske Melis Gökçe Çeldir İlayda Arjen Kara Natalia Pshenichnaya Gulzhan Abuova Lucille Blumberg Mehmet Gönen |
| author_sort | Önder Ergönül |
| collection | DOAJ |
| description | We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0–0.03), and ribavirin use <48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0–0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection. |
| first_indexed | 2024-12-14T11:58:10Z |
| format | Article |
| id | doaj.art-ec11987916c44ac1bcb9dcb69382b038 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T11:58:10Z |
| publishDate | 2018-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-ec11987916c44ac1bcb9dcb69382b0382022-12-21T23:02:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-09-012491642164810.3201/eid2409.171709Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare WorkersÖnder ErgönülŞiran KeskeMelis Gökçe Çeldirİlayda Arjen KaraNatalia PshenichnayaGulzhan AbuovaLucille BlumbergMehmet GönenWe performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0–0.03), and ribavirin use <48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0–0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection.https://wwwnc.cdc.gov/eid/article/24/9/17-1709_articleCrimean-Congo hemorrhagic feverribavirinhealthcare workerspost-exposure prophylaxisearly treatmentCCHF |
| spellingShingle | Önder Ergönül Şiran Keske Melis Gökçe Çeldir İlayda Arjen Kara Natalia Pshenichnaya Gulzhan Abuova Lucille Blumberg Mehmet Gönen Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers Emerging Infectious Diseases Crimean-Congo hemorrhagic fever ribavirin healthcare workers post-exposure prophylaxis early treatment CCHF |
| title | Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers |
| title_full | Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers |
| title_fullStr | Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers |
| title_full_unstemmed | Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers |
| title_short | Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers |
| title_sort | systematic review and meta analysis of postexposure prophylaxis for crimean congo hemorrhagic fever virus among healthcare workers |
| topic | Crimean-Congo hemorrhagic fever ribavirin healthcare workers post-exposure prophylaxis early treatment CCHF |
| url | https://wwwnc.cdc.gov/eid/article/24/9/17-1709_article |
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