Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model
<p>Abstract</p> <p>Several animal models have been established to study visceral leishmaniosis (VL), a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem. BALB/c mice and Syrian hamsters are the most widely used exp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-02-01
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| Series: | Veterinary Research |
| Online Access: | http://www.veterinaryresearch.org/content/42/1/39 |
| _version_ | 1817994224885301248 |
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| author | Nieto Ana Domínguez-Bernal Gustavo Orden José A De La Fuente Ricardo Madrid-Elena Nadia Carrión Javier |
| author_facet | Nieto Ana Domínguez-Bernal Gustavo Orden José A De La Fuente Ricardo Madrid-Elena Nadia Carrión Javier |
| author_sort | Nieto Ana |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Several animal models have been established to study visceral leishmaniosis (VL), a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem. BALB/c mice and Syrian hamsters are the most widely used experimental models. In this paper, we summarize the advantages and disadvantages of these two experimental models and discuss the results obtained using these models in different studies of VL. Studies using the BALB/c mouse model have underscored differences between the liver and spleen in the course of VL, indicating that pathological evaluation of the visceral organs is essential for understanding the immune mechanisms induced by <it>Leishmania infantum </it>infection. The main goal of this review is to collate the relevant literature on <it>Leishmania </it>pathogenesis into a sequence of events, providing a schematic view of the main components of adaptive and innate immunity in the liver and spleen after experimental infection with <it>L. infantum or L. donovani</it>. This review also presents several viewpoints and reflections about some controversial aspects of <it>Leishmania </it>research, including the choice of experimental model, route of administration, inoculum size and the relevance of pathology (intimately linked to parasite persistence): a thorough understanding of which is essential for future VL research and the successful development of efficient control strategies for <it>Leishmania spp</it>.</p> |
| first_indexed | 2024-04-14T01:49:11Z |
| format | Article |
| id | doaj.art-ec11e4b50e11420a93f013d3847ab7b3 |
| institution | Directory Open Access Journal |
| issn | 0928-4249 1297-9716 |
| language | English |
| last_indexed | 2024-04-14T01:49:11Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj.art-ec11e4b50e11420a93f013d3847ab7b32022-12-22T02:19:24ZengBMCVeterinary Research0928-42491297-97162011-02-014213910.1186/1297-9716-42-39Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster modelNieto AnaDomínguez-Bernal GustavoOrden José ADe La Fuente RicardoMadrid-Elena NadiaCarrión Javier<p>Abstract</p> <p>Several animal models have been established to study visceral leishmaniosis (VL), a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem. BALB/c mice and Syrian hamsters are the most widely used experimental models. In this paper, we summarize the advantages and disadvantages of these two experimental models and discuss the results obtained using these models in different studies of VL. Studies using the BALB/c mouse model have underscored differences between the liver and spleen in the course of VL, indicating that pathological evaluation of the visceral organs is essential for understanding the immune mechanisms induced by <it>Leishmania infantum </it>infection. The main goal of this review is to collate the relevant literature on <it>Leishmania </it>pathogenesis into a sequence of events, providing a schematic view of the main components of adaptive and innate immunity in the liver and spleen after experimental infection with <it>L. infantum or L. donovani</it>. This review also presents several viewpoints and reflections about some controversial aspects of <it>Leishmania </it>research, including the choice of experimental model, route of administration, inoculum size and the relevance of pathology (intimately linked to parasite persistence): a thorough understanding of which is essential for future VL research and the successful development of efficient control strategies for <it>Leishmania spp</it>.</p>http://www.veterinaryresearch.org/content/42/1/39 |
| spellingShingle | Nieto Ana Domínguez-Bernal Gustavo Orden José A De La Fuente Ricardo Madrid-Elena Nadia Carrión Javier Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model Veterinary Research |
| title | Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model |
| title_full | Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model |
| title_fullStr | Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model |
| title_full_unstemmed | Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model |
| title_short | Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster model |
| title_sort | mechanisms of resistance and susceptibility to experimental visceral leishmaniosis balb c mouse versus syrian hamster model |
| url | http://www.veterinaryresearch.org/content/42/1/39 |
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