New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens

New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens

The tetracycline repressor (tetR)‐regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line, which allows for the inducible expression of an EGFP fusion of the TAR DNA‐binding protein 43 (TDP‐4...

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Bibliographic Details
Main Authors: Valeria Colicchia, Maria Häggblad, Oleksandra Sirozh, Bartlomiej Porebski, Mirela Balan, Xuexin Li, Louise Lidemalm, Jordi Carreras‐Puigvert, Daniela Hühn, Oscar Fernandez‐Capetillo
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:FEBS Open Bio
Subjects:
ALS
chemical screen
doxycycline
TDP‐43
tetR
Online Access:https://doi.org/10.1002/2211-5463.13482

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