Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis

Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis

Abstract Objectives Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for rheumatoid arthritis (RA). Methods HDAC6 was overexpressed in mouse peri...

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Bibliographic Details
Main Authors: Jin Kyun Park, Yu Jin Jang, Bo Ram Oh, Jieun Shin, Daekwon Bae, Nina Ha, Young il Choi, Gi Soo Youn, Jinseu Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
HDAC6
Inflammation
Inhibitor
Drug
Online Access:http://link.springer.com/article/10.1186/s13075-020-02258-0

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