Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection
Abstract Background Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric inflammation and higher prevalence of precancerous lesions than non-diab...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-10-01
|
| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12929-017-0389-x |
| _version_ | 1818084342669246464 |
|---|---|
| author | Yao-Jong Yang Chung-Tai Wu Horng-Yih Ou Chin-Han Lin Hsiu-Chi Cheng Wei-Lun Chang Wei-Ying Chen Hsiao-Bai Yang Cheng-Chan Lu Bor-Shyang Sheu |
| author_facet | Yao-Jong Yang Chung-Tai Wu Horng-Yih Ou Chin-Han Lin Hsiu-Chi Cheng Wei-Lun Chang Wei-Ying Chen Hsiao-Bai Yang Cheng-Chan Lu Bor-Shyang Sheu |
| author_sort | Yao-Jong Yang |
| collection | DOAJ |
| description | Abstract Background Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric inflammation and higher prevalence of precancerous lesions than non-diabetic controls. Methods A total of 797 patients with type 2 diabetes mellitus were screened for H. pylori, of whom 264 had H. pylori infection. Of these patients, 129 received esophagogastroduodenoscopy to obtain topographic gastric specimens for gastric histology according to the modified Updated Sydney System, corpus-predominant gastritis index (CGI), Operative Link on Gastritis Assessment, and Operative Link on Gastric Intestinal Metaplasia Assessment. Non-diabetic dyspeptic patients who had H. pylori infection confirmed by esophagogastroduodenoscopy were enrolled as controls. Results The male as well as total T2DM patients had higher acute/chronic inflammatory and lymphoid follicle scores in the corpus than non-diabetic controls (p < 0.05). In contrast, the female T2DM patients had higher chronic inflammatory scores in the antrum than the controls (p < 0.05). In T2DM patients, the males had significantly higher rates of CGI than the females (p < 0.05). Multivariate logistic regression analysis showed that male patients (odds ratio: 2.28, 95% confidence interval: 1.11–4.69, p = 0.025) and non-insulin users (odds ratio: 0.33, 95% confidence interval: 0.15–0.74, p = 0.007) were independent factors for the presence of CGI in the H. pylori-infected patients with type 2 diabetes mellitus. Conclusions Patients with type 2 diabetes mellitus and H. pylori infection had more severe corpus gastric inflammation than non-diabetic controls. Moreover, male gender and non-insulin users of T2DM patients were predisposed to have corpus-predominant gastritis after H. pylori infection. Trial registration ClinicalTrial: NCT02466919 , retrospectively registered may 17, 2015. |
| first_indexed | 2024-12-10T19:52:22Z |
| format | Article |
| id | doaj.art-ec137c7867b14ebd94d47894af716b78 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-12-10T19:52:22Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-ec137c7867b14ebd94d47894af716b782022-12-22T01:35:45ZengBMCJournal of Biomedical Science1423-01272017-10-012411810.1186/s12929-017-0389-xMale non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infectionYao-Jong Yang0Chung-Tai Wu1Horng-Yih Ou2Chin-Han Lin3Hsiu-Chi Cheng4Wei-Lun Chang5Wei-Ying Chen6Hsiao-Bai Yang7Cheng-Chan Lu8Bor-Shyang Sheu9Departments of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityPathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityPathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInternal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityAbstract Background Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric inflammation and higher prevalence of precancerous lesions than non-diabetic controls. Methods A total of 797 patients with type 2 diabetes mellitus were screened for H. pylori, of whom 264 had H. pylori infection. Of these patients, 129 received esophagogastroduodenoscopy to obtain topographic gastric specimens for gastric histology according to the modified Updated Sydney System, corpus-predominant gastritis index (CGI), Operative Link on Gastritis Assessment, and Operative Link on Gastric Intestinal Metaplasia Assessment. Non-diabetic dyspeptic patients who had H. pylori infection confirmed by esophagogastroduodenoscopy were enrolled as controls. Results The male as well as total T2DM patients had higher acute/chronic inflammatory and lymphoid follicle scores in the corpus than non-diabetic controls (p < 0.05). In contrast, the female T2DM patients had higher chronic inflammatory scores in the antrum than the controls (p < 0.05). In T2DM patients, the males had significantly higher rates of CGI than the females (p < 0.05). Multivariate logistic regression analysis showed that male patients (odds ratio: 2.28, 95% confidence interval: 1.11–4.69, p = 0.025) and non-insulin users (odds ratio: 0.33, 95% confidence interval: 0.15–0.74, p = 0.007) were independent factors for the presence of CGI in the H. pylori-infected patients with type 2 diabetes mellitus. Conclusions Patients with type 2 diabetes mellitus and H. pylori infection had more severe corpus gastric inflammation than non-diabetic controls. Moreover, male gender and non-insulin users of T2DM patients were predisposed to have corpus-predominant gastritis after H. pylori infection. Trial registration ClinicalTrial: NCT02466919 , retrospectively registered may 17, 2015.http://link.springer.com/article/10.1186/s12929-017-0389-xH. PyloriType 2 diabetes mellitusGastric cancerGenderInsulin |
| spellingShingle | Yao-Jong Yang Chung-Tai Wu Horng-Yih Ou Chin-Han Lin Hsiu-Chi Cheng Wei-Lun Chang Wei-Ying Chen Hsiao-Bai Yang Cheng-Chan Lu Bor-Shyang Sheu Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection Journal of Biomedical Science H. Pylori Type 2 diabetes mellitus Gastric cancer Gender Insulin |
| title | Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection |
| title_full | Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection |
| title_fullStr | Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection |
| title_full_unstemmed | Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection |
| title_short | Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection |
| title_sort | male non insulin users with type 2 diabetes mellitus are predisposed to gastric corpus predominant inflammation after h pylori infection |
| topic | H. Pylori Type 2 diabetes mellitus Gastric cancer Gender Insulin |
| url | http://link.springer.com/article/10.1186/s12929-017-0389-x |
| work_keys_str_mv | AT yaojongyang malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT chungtaiwu malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT horngyihou malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT chinhanlin malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT hsiuchicheng malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT weilunchang malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT weiyingchen malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT hsiaobaiyang malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT chengchanlu malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection AT borshyangsheu malenoninsulinuserswithtype2diabetesmellitusarepredisposedtogastriccorpuspredominantinflammationafterhpyloriinfection |