Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study
Introduction: Zinc deficiency has been reported in patients with both hepatitis C and beta thalassemia major. Zinc supplementation in addition to antiviral therapy of chronic hepatitis C has been accompanied by some success in patients with chronic hepatitis C. Objective: The aim of the present...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5305/10403_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdf |
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| author | Mohammad Abbasinazari Seyed Moayed Alavian Bita Behnava Mansour Asgharinia Shima Salimi Maryam Keshvari Leala Mehrnoush Pegah Karim |
| author_facet | Mohammad Abbasinazari Seyed Moayed Alavian Bita Behnava Mansour Asgharinia Shima Salimi Maryam Keshvari Leala Mehrnoush Pegah Karim |
| author_sort | Mohammad Abbasinazari |
| collection | DOAJ |
| description | Introduction: Zinc deficiency has been reported in patients
with both hepatitis C and beta thalassemia major. Zinc
supplementation in addition to antiviral therapy of chronic
hepatitis C has been accompanied by some success in patients
with chronic hepatitis C.
Objective: The aim of the present pilot study is to determine the
effect of 30 mg elemental zinc on biochemical and virological
response in a population of patients with chronic hepatitis C
with beta thalassemia major.
Materials and Methods: A prospective, double blind,placebo
controlled trial included 40 patients being treated with Pegylated
interferon Alfa (Peg IFN-α) and ribavirin. Biochemical and
virological parameters and plasma zinc levels were determined
before starting treatment. Patients were randomly selected to
receive either zinc or a placebo in addition to Peg IFN-α and
ribavirin for a period of one year. AST, ALT, sustained viral
response (SVR), and zinc levels were measured after treatment.
Of the original 40 eligible patients, eight withdrawn from the
study and 32 patients completed the study; 16 in the zinc group
and 16 in the placebo group. Analysis of the data shows that
there is no difference between the two groups in AST, ALT, SVR
or zinc level following one year of treatment (p=0.224, p=0.616,
p=0.670, p=0.999, respectively).
Conclusion:The results of this study indicate that using 30 mg/
day elemental zinc did not significantly improve the outcome
of treatment in thalassemia patients with chronic hepatitis C.
In future studies, we recommend trying higher doses zinc in
patients with hepatitis C who had beta thalassemia major. |
| first_indexed | 2024-12-19T14:19:39Z |
| format | Article |
| id | doaj.art-ec1530a2559047f9b76c09e0f2001694 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T14:19:39Z |
| publishDate | 2014-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-ec1530a2559047f9b76c09e0f20016942022-12-21T20:17:49ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-12-01812HC16HC1910.7860/JCDR/2014/10403.5305Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot StudyMohammad Abbasinazari0Seyed Moayed Alavian1Bita Behnava2Mansour Asgharinia3Shima Salimi4Maryam Keshvari5Leala Mehrnoush6Pegah Karim7Faculty, Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Faculty, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran; Middle East Liver Disease,Tehran, Iran.Faculty, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.Faculty, Students Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Faculty, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.Faculty, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.Faculty, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.Faculty, Iranian Blood Transfusion Organization Reaserch Center, Tehran, Iran.Introduction: Zinc deficiency has been reported in patients with both hepatitis C and beta thalassemia major. Zinc supplementation in addition to antiviral therapy of chronic hepatitis C has been accompanied by some success in patients with chronic hepatitis C. Objective: The aim of the present pilot study is to determine the effect of 30 mg elemental zinc on biochemical and virological response in a population of patients with chronic hepatitis C with beta thalassemia major. Materials and Methods: A prospective, double blind,placebo controlled trial included 40 patients being treated with Pegylated interferon Alfa (Peg IFN-α) and ribavirin. Biochemical and virological parameters and plasma zinc levels were determined before starting treatment. Patients were randomly selected to receive either zinc or a placebo in addition to Peg IFN-α and ribavirin for a period of one year. AST, ALT, sustained viral response (SVR), and zinc levels were measured after treatment. Of the original 40 eligible patients, eight withdrawn from the study and 32 patients completed the study; 16 in the zinc group and 16 in the placebo group. Analysis of the data shows that there is no difference between the two groups in AST, ALT, SVR or zinc level following one year of treatment (p=0.224, p=0.616, p=0.670, p=0.999, respectively). Conclusion:The results of this study indicate that using 30 mg/ day elemental zinc did not significantly improve the outcome of treatment in thalassemia patients with chronic hepatitis C. In future studies, we recommend trying higher doses zinc in patients with hepatitis C who had beta thalassemia major.https://jcdr.net/articles/PDF/5305/10403_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdfbeta thalassemia majorhepatitis csvrzinc |
| spellingShingle | Mohammad Abbasinazari Seyed Moayed Alavian Bita Behnava Mansour Asgharinia Shima Salimi Maryam Keshvari Leala Mehrnoush Pegah Karim Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study Journal of Clinical and Diagnostic Research beta thalassemia major hepatitis c svr zinc |
| title | Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study |
| title_full | Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study |
| title_fullStr | Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study |
| title_full_unstemmed | Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study |
| title_short | Effect of Zinc Supplementation on Viral Response in Patients with Chronic Hepatitis C and Beta Thalassemia Major, A Pilot Study |
| title_sort | effect of zinc supplementation on viral response in patients with chronic hepatitis c and beta thalassemia major a pilot study |
| topic | beta thalassemia major hepatitis c svr zinc |
| url | https://jcdr.net/articles/PDF/5305/10403_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdf |
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