3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with adverse outcomes that have barely improved over the last decade. About half of all patients present with metastasis at the time of diagnosis, and the 5-year overall survival rate across all stages is only 6%. Innovative in vi...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/15/3733 |
| _version_ | 1797442605081952256 |
|---|---|
| author | Eric Pion Julia Karnosky Sofie Boscheck Benedikt J. Wagner Katharina M. Schmidt Stefan M. Brunner Hans J. Schlitt Thiha Aung Christina Hackl Silke Haerteis |
| author_facet | Eric Pion Julia Karnosky Sofie Boscheck Benedikt J. Wagner Katharina M. Schmidt Stefan M. Brunner Hans J. Schlitt Thiha Aung Christina Hackl Silke Haerteis |
| author_sort | Eric Pion |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with adverse outcomes that have barely improved over the last decade. About half of all patients present with metastasis at the time of diagnosis, and the 5-year overall survival rate across all stages is only 6%. Innovative in vivo research models are necessary to combat this cancer and to discover novel treatment strategies. The chorioallantoic membrane (CAM) model represents one 3D in vivo methodology that has been used in a large number of studies on different cancer types for over a century. This model is based on a membrane formed within fertilized chicken eggs that contain a dense network of blood vessels. Because of its high cost-efficiency, simplicity, and versatility, the CAM model appears to be a highly valuable research tool in the pursuit of gaining more in-depth insights into PDAC. A summary of the current literature on the usage of the CAM model for the investigation of PDAC was conducted and subdivided into angiogenesis, drug testing, modifications, personalized medicine, and further developments. On this comprehensive basis, further research should be conducted on PDAC in order to improve the abysmal prognosis of this malignant disease. |
| first_indexed | 2024-03-09T12:44:22Z |
| format | Article |
| id | doaj.art-ec1548f9b2e24db4ba8381d09d8ecd6b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:44:22Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ec1548f9b2e24db4ba8381d09d8ecd6b2023-11-30T22:14:29ZengMDPI AGCancers2072-66942022-07-011415373310.3390/cancers141537333D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) ModelEric Pion0Julia Karnosky1Sofie Boscheck2Benedikt J. Wagner3Katharina M. Schmidt4Stefan M. Brunner5Hans J. Schlitt6Thiha Aung7Christina Hackl8Silke Haerteis9Institute for Molecular and Cellular Anatomy, University of Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute for Molecular and Cellular Anatomy, University of Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute for Molecular and Cellular Anatomy, University of Regensburg, 93053 Regensburg, GermanyDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute for Molecular and Cellular Anatomy, University of Regensburg, 93053 Regensburg, GermanyPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with adverse outcomes that have barely improved over the last decade. About half of all patients present with metastasis at the time of diagnosis, and the 5-year overall survival rate across all stages is only 6%. Innovative in vivo research models are necessary to combat this cancer and to discover novel treatment strategies. The chorioallantoic membrane (CAM) model represents one 3D in vivo methodology that has been used in a large number of studies on different cancer types for over a century. This model is based on a membrane formed within fertilized chicken eggs that contain a dense network of blood vessels. Because of its high cost-efficiency, simplicity, and versatility, the CAM model appears to be a highly valuable research tool in the pursuit of gaining more in-depth insights into PDAC. A summary of the current literature on the usage of the CAM model for the investigation of PDAC was conducted and subdivided into angiogenesis, drug testing, modifications, personalized medicine, and further developments. On this comprehensive basis, further research should be conducted on PDAC in order to improve the abysmal prognosis of this malignant disease.https://www.mdpi.com/2072-6694/14/15/3733pancreatic cancerpancreatic ductal adenocarcinoma (PDAC)chorioallantoic membrane (CAM) model3D in vivo model |
| spellingShingle | Eric Pion Julia Karnosky Sofie Boscheck Benedikt J. Wagner Katharina M. Schmidt Stefan M. Brunner Hans J. Schlitt Thiha Aung Christina Hackl Silke Haerteis 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model Cancers pancreatic cancer pancreatic ductal adenocarcinoma (PDAC) chorioallantoic membrane (CAM) model 3D in vivo model |
| title | 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model |
| title_full | 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model |
| title_fullStr | 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model |
| title_full_unstemmed | 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model |
| title_short | 3D In Vivo Models for Translational Research on Pancreatic Cancer: The Chorioallantoic Membrane (CAM) Model |
| title_sort | 3d in vivo models for translational research on pancreatic cancer the chorioallantoic membrane cam model |
| topic | pancreatic cancer pancreatic ductal adenocarcinoma (PDAC) chorioallantoic membrane (CAM) model 3D in vivo model |
| url | https://www.mdpi.com/2072-6694/14/15/3733 |
| work_keys_str_mv | AT ericpion 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT juliakarnosky 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT sofieboscheck 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT benediktjwagner 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT katharinamschmidt 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT stefanmbrunner 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT hansjschlitt 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT thihaaung 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT christinahackl 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel AT silkehaerteis 3dinvivomodelsfortranslationalresearchonpancreaticcancerthechorioallantoicmembranecammodel |