Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults

Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults

Abstract Background Dysregulation of lipid metabolism is the most prominent metabolic alteration observed in obesity, cancer, and cardiovascular diseases. The present study aimed to explore the sex differences associated with lipid metabolism in urinary exosome proteins, and evaluate the correlation...

Full description

Bibliographic Details
Main Authors:	Tao Li, Wen Meng, Tian Ci Liu, Yi Zhao Wang, Man Zhang
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Lipids in Health and Disease
Subjects:	Urinary exosomes Fatty acid synthesis FASN Sex differences Triglyceride
Online Access:	https://doi.org/10.1186/s12944-023-01936-7

Similar Items

Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer
by: Lingyu Han, et al.
Published: (2023-01-01)

Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL
by: Cheng Chi, et al.
Published: (2022-09-01)

FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma
by: Ugo Chianese, et al.
Published: (2023-01-01)

FASN-Mediated Lipid Metabolism Regulates Goose Granulosa Cells Apoptosis and Steroidogenesis
by: Xi Chen, et al.
Published: (2020-06-01)

Evaluation of SCD and FASN Gene Expression in Baluchi, Iran-Black, and Arman Sheep
by: Mohammad Salmani Izadi, et al.
Published: (2016-10-01)

SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer
by: Yuxiao Jin, et al.
Published: (2021-05-01)

Characterization of Total RNA, CD44, FASN, and PTEN mRNAs from Extracellular Vesicles as Biomarkers in Gastric Cancer Patients
by: Philipp Rhode, et al.
Published: (2021-11-01)

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses
by: Katrina Mekhail, et al.
Published: (2022-09-01)

Protective effect of triclosan in monocrotaline-induced pulmonary arterial hypertension: FASN inhibition a novel approach
by: Nimer Alsabeelah, et al.
Published: (2022-01-01)

Association study between g.16024A>G polymorphism of the FASN gene and milk production of Holstein cattle
by: Martina Miluchová, et al.
Published: (2023-03-01)

MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study
by: Weihua Jiang, et al.
Published: (2021-05-01)

The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
by: G. N. A. Winarno, et al.
Published: (2020-07-01)

Análisis de polimorfismo de nucleótido simple en el gen FASN y su relación con características de producción en pollos
by: MARRUBE, G., et al.
Published: (2013-04-01)

Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice
by: Khan A, et al.
Published: (2020-12-01)

Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations
by: Serena Stamatakos, et al.
Published: (2021-05-01)

Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
by: Qiuhong Xiong, et al.
Published: (2024-03-01)

Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population
by: Yu Yu, et al.
Published: (2023-06-01)

α-Hederin Regulates SREBP1/FASN Pathway and Inhibits Malignant Phenotype of Non-small Cell Lung Cancer
by: CHANG Yuzhen, et al.
Published: (2023-08-01)

SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract
by: Andrea Floris, et al.
Published: (2020-03-01)

Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats
by: Joanna Nowacka-Woszuk, et al.
Published: (2017-08-01)

Variation in the Fatty Acid Synthase Gene (<em>FASN</em>) and Its Association with Milk Traits in Gannan Yaks
by: Bingang Shi, et al.
Published: (2019-08-01)

Comprehensive Analysis of FASN in Tumor Immune Infiltration and Prognostic Value for Immunotherapy and Promoter DNA Methylation
by: Mingyang Zhang, et al.
Published: (2022-12-01)

The Pharmacological or Genetic Blockade of Endogenous De Novo Fatty Acid Synthesis Does Not Increase the Uptake of Exogenous Lipids in Ovarian Cancer Cells
by: Thomas W. Grunt, et al.
Published: (2021-04-01)

Developmental patterns of FASN and LIPE mRNA expression in adipose tissue of growing Jinhua and Landrace gilts
by: Z. Miao, et al.
Published: (2010-12-01)

Sex and Age Differences Modulate Association of Vitamin D with Serum Triglyceride Levels
by: Ying-Lien Cheng, et al.
Published: (2022-03-01)

Análisis de polimorfismo de nucleótido simple en el gen FASN y su relación con características de producción en pollos
by: G. MARRUBE, et al.
Published: (2013-01-01)

KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma
by: Bo Zhang, et al.
Published: (2020-06-01)

The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer
by: Juhong Wang, et al.
Published: (2022-07-01)

Ectopic OR1A1 activation ameliorates hepatic lipid deposition through AMPK/SREBP-1/FASN pathway by three monoterpenes
by: Shuwei Ke, et al.
Published: (2024-04-01)

Urinary exosome proteins PAK6 and EGFR as noninvasive diagnostic biomarkers of diabetic nephropathy
by: Tao Li, et al.
Published: (2023-10-01)

Urinary exosomes: Emerging therapy delivery tools and biomarkers for urinary system diseases
by: Xin Li, et al.
Published: (2022-06-01)

Sex differences in lower urinary tract biology and physiology
by: Benjamin Abelson, et al.
Published: (2018-10-01)

Synthesis Of Light Colour Medium Chain Triglycerides From Palm Kernel Oil Products
by: Jamaludin, Radzuan
Published: (1999)

FASN negatively regulates p65 expression by reducing its stability via Thr254 phosphorylation and isomerization by Pin1
by: Lincoln Barlow, et al.
Published: (2024-04-01)

High-purified Isolation and Proteomic Analysis of Urinary Exosomes from Healthy Persons
by: Meng Yang, et al.
Published: (2017-09-01)

Urinary Exosomal MicroRNAs as Biomarkers for Obesity-Associated Chronic Kidney Disease
by: Angel Earle, et al.
Published: (2022-09-01)

Establishment of urinary exosome-like vesicles isolation protocol for FHHNC patients and evaluation of different exosomal RNA extraction methods
by: M. Vall-Palomar, et al.
Published: (2018-10-01)

α-Lipoic Acid Alleviates Hepatic Lipid Deposition by Inhibiting FASN Expression via miR-3548 in Rats
by: Shihui Guo, et al.
Published: (2021-07-01)

SGIV Induced and Exploited Cellular De Novo Fatty Acid Synthesis for Virus Entry and Replication
by: Qi Zheng, et al.
Published: (2022-01-01)

Fatty acid synthase as a potential new therapeutic target for cervical cancer
by: JÉSSICA NASCIMENTO, et al.
Published: (2022-05-01)