Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against <i>Trypanosoma cruzi</i>

Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against <i>Trypanosoma cruzi</i>

Chagas disease, a chronic and silent disease caused by <i>Trypanosoma cruzi</i>, is currently a global public health problem. The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited efficacy and severe side effects. The...

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Bibliographic Details
Main Authors: Lorraine Martins Rocha Orlando, Guilherme Curty Lechuga, Leonardo da Silva Lara, Byanca Silva Ferreira, Cynthia Nathalia Pereira, Rafaela Corrêa Silva, Maurício Silva dos Santos, Mirian Claudia S. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
<i>Trypanosoma cruzi</i>
pyrazole derivatives
trypanocidal activity
3D culture model
Online Access:https://www.mdpi.com/1420-3049/26/21/6742

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