Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study
Abstract Background Nausea and vomiting of pregnancy (NVP) is common and underlying mechanisms are poorly understood. Longer-term offspring outcomes are also not well documented. This study aimed to determine if NVP, even in milder forms, is associated with adverse pregnancy and childhood growth out...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-021-04024-9 |
| _version_ | 1818586922311745536 |
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| author | Judith Ong Suresh Anand Sadananthan Shu-E Soh Sharon Ng Wen Lun Yuan Izzuddin M Aris Mya Thway Tint Navin Michael See Ling Loy Kok Hian Tan Keith M Godfrey Lynette P Shek Fabian Yap Yung Seng Lee Yap Seng Chong Shiao-Yng Chan |
| author_facet | Judith Ong Suresh Anand Sadananthan Shu-E Soh Sharon Ng Wen Lun Yuan Izzuddin M Aris Mya Thway Tint Navin Michael See Ling Loy Kok Hian Tan Keith M Godfrey Lynette P Shek Fabian Yap Yung Seng Lee Yap Seng Chong Shiao-Yng Chan |
| author_sort | Judith Ong |
| collection | DOAJ |
| description | Abstract Background Nausea and vomiting of pregnancy (NVP) is common and underlying mechanisms are poorly understood. Longer-term offspring outcomes are also not well documented. This study aimed to determine if NVP, even in milder forms, is associated with adverse pregnancy and childhood growth outcomes. Methods In the GUSTO prospective mother-offspring cohort, women with singleton pregnancies (n = 1172) recruited in first trimester responded to interviewer-administered questions at 26–28 weeks’ gestation about earlier episodes of NVP since becoming pregnant. Pregnancy outcomes were obtained from medical records. Offspring height and weight measured at 15 time-points between birth to 72 months (m) were standardised for age and sex. Results 58.5% (n = 686) reported mild-moderate vomiting (mNVP), 10.5% (n = 123) severe vomiting (sNVP) and 5.7% (n = 67) severe vomiting with hospitalisation (shNVP). There was no difference in odds of gestational diabetes, hypertensive disorders of pregnancy, labour induction or caesarean section after adjustment for covariates. sNVP was associated with late preterm delivery [34+ 0–36+ 6 weeks’, adjusted OR = 3.04 (95% CI 1.39,6.68)], without increased odds of neonatal unit admission. Compared with no NVP, boys born to mothers with sNVP were longer at birth [adjusted β = 0.38 standard deviations (SDs) (95% CI 0.02,0.73)], remained taller [0.64 SDs (0.23,1.04) at 72 m] and heavier [0.57 SDs (0.05,1.08) at 60 m] without differences in BMI. Conversely, girls born to mothers with shNVP were lighter from 48 m [− 0.52 SDs (− 1.00, − 0.03)] onwards with lower BMI [− 0.61 SDs (− 1.12,-0.09)]. Conditional growth modelling revealed significant sex-divergence in weight-gain at birth-3 m, 6-9 m and 4–5 years. Conclusions Severe NVP was associated with late preterm delivery, and both mild-moderate and severe NVP associated with sex-dependent differences in early childhood growth. Boys whose mothers had NVP were taller and heavier from birth with faster growth in the first year, whereas, girls had poorer weight gain and were lighter by 48 m. As even milder severities of NVP could have long-term impact on offspring growth, further research is needed to determine mechanisms involved and implications on future health. Trial registration Clinicaltrials.gov identifier NCT01174875 . |
| first_indexed | 2024-12-16T09:00:39Z |
| format | Article |
| id | doaj.art-ec165dff932a4de893f5c283bfcbba53 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-16T09:00:39Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-ec165dff932a4de893f5c283bfcbba532022-12-21T22:37:12ZengBMCBMC Pregnancy and Childbirth1471-23932021-08-0121111110.1186/s12884-021-04024-9Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort studyJudith Ong0Suresh Anand Sadananthan1Shu-E Soh2Sharon Ng3Wen Lun Yuan4Izzuddin M Aris5Mya Thway Tint6Navin Michael7See Ling Loy8Kok Hian Tan9Keith M Godfrey10Lynette P Shek11Fabian Yap12Yung Seng Lee13Yap Seng Chong14Shiao-Yng Chan15Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore Institute for Clinical Sciences, A*STARDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Population Medicine, Division of Chronic Disease Research Across the Lifecourse, Harvard Medical School and Harvard Pilgrim Health Care InstituteDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore Institute for Clinical Sciences, A*STARSingapore Institute for Clinical Sciences, A*STARDuke-NUS Medical SchoolMRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation TrustSingapore Institute for Clinical Sciences, A*STARDuke-NUS Medical SchoolSingapore Institute for Clinical Sciences, A*STARDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of SingaporeAbstract Background Nausea and vomiting of pregnancy (NVP) is common and underlying mechanisms are poorly understood. Longer-term offspring outcomes are also not well documented. This study aimed to determine if NVP, even in milder forms, is associated with adverse pregnancy and childhood growth outcomes. Methods In the GUSTO prospective mother-offspring cohort, women with singleton pregnancies (n = 1172) recruited in first trimester responded to interviewer-administered questions at 26–28 weeks’ gestation about earlier episodes of NVP since becoming pregnant. Pregnancy outcomes were obtained from medical records. Offspring height and weight measured at 15 time-points between birth to 72 months (m) were standardised for age and sex. Results 58.5% (n = 686) reported mild-moderate vomiting (mNVP), 10.5% (n = 123) severe vomiting (sNVP) and 5.7% (n = 67) severe vomiting with hospitalisation (shNVP). There was no difference in odds of gestational diabetes, hypertensive disorders of pregnancy, labour induction or caesarean section after adjustment for covariates. sNVP was associated with late preterm delivery [34+ 0–36+ 6 weeks’, adjusted OR = 3.04 (95% CI 1.39,6.68)], without increased odds of neonatal unit admission. Compared with no NVP, boys born to mothers with sNVP were longer at birth [adjusted β = 0.38 standard deviations (SDs) (95% CI 0.02,0.73)], remained taller [0.64 SDs (0.23,1.04) at 72 m] and heavier [0.57 SDs (0.05,1.08) at 60 m] without differences in BMI. Conversely, girls born to mothers with shNVP were lighter from 48 m [− 0.52 SDs (− 1.00, − 0.03)] onwards with lower BMI [− 0.61 SDs (− 1.12,-0.09)]. Conditional growth modelling revealed significant sex-divergence in weight-gain at birth-3 m, 6-9 m and 4–5 years. Conclusions Severe NVP was associated with late preterm delivery, and both mild-moderate and severe NVP associated with sex-dependent differences in early childhood growth. Boys whose mothers had NVP were taller and heavier from birth with faster growth in the first year, whereas, girls had poorer weight gain and were lighter by 48 m. As even milder severities of NVP could have long-term impact on offspring growth, further research is needed to determine mechanisms involved and implications on future health. Trial registration Clinicaltrials.gov identifier NCT01174875 .https://doi.org/10.1186/s12884-021-04024-9Hyperemesis gravidarumPremature birthChild anthropometryChild growth |
| spellingShingle | Judith Ong Suresh Anand Sadananthan Shu-E Soh Sharon Ng Wen Lun Yuan Izzuddin M Aris Mya Thway Tint Navin Michael See Ling Loy Kok Hian Tan Keith M Godfrey Lynette P Shek Fabian Yap Yung Seng Lee Yap Seng Chong Shiao-Yng Chan Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study BMC Pregnancy and Childbirth Hyperemesis gravidarum Premature birth Child anthropometry Child growth |
| title | Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study |
| title_full | Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study |
| title_fullStr | Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study |
| title_full_unstemmed | Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study |
| title_short | Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study |
| title_sort | increasing nausea and vomiting of pregnancy is associated with sex dependent differences in early childhood growth the gusto mother offspring cohort study |
| topic | Hyperemesis gravidarum Premature birth Child anthropometry Child growth |
| url | https://doi.org/10.1186/s12884-021-04024-9 |
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