| Summary: | The present study aimed to determine a method for estimating a potential
prognostic factor in alternating electric fields for the treatment of solid
tumors based on cell survival curves that evaluate cell proliferation
capability. In AGS, B16F10, U373, and HPAF-II cancer cell lines, the
proportional relationships of the electric field magnitude and the duration of
application with the proliferation of cancer cell lines was identified by
in vitro alternating current electric field experiments
performed under various conditions. A prognostic factor applicable to
alternating electric field therapy was developed by identifying proportional
relationships of the electric field magnitude and the duration of application
with the proliferation of the four cancer cell lines. Through the experimental
results, the absorbed energy in tissue has been suggested as a potential
prognostic factor in alternating electric field therapy. The absorbed energy in
tissue can be used as a reference to quantify the inhibition of cell
proliferation related to control, enabling systematic assessment of alternating
electric field therapy which, to date, has not been possible.
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