The clinical significance of ARID1A mutations in gastric cancer patients
Background: ARID1A is a key component of the SWI/SNF chromatin remodeling complex, which has been identified in various cancers. Loss of ARID1A expression is correlated with poor prognosis in gastric cancer (GC); however, the clinical relevance of ARID1A mutations in GC has not yet been reported. Ma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2020-01-01
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| Series: | Formosan Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2020;volume=53;issue=3;spage=93;epage=100;aulast=Wu |
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| author | Chia-Hung Wu Chien-Hsun Tseng Kuo-Hung Huang Wen-Liang Fang Ming-Huang Chen Anna Fen-Yau Li Chew-Wun Wu |
| author_facet | Chia-Hung Wu Chien-Hsun Tseng Kuo-Hung Huang Wen-Liang Fang Ming-Huang Chen Anna Fen-Yau Li Chew-Wun Wu |
| author_sort | Chia-Hung Wu |
| collection | DOAJ |
| description | Background: ARID1A is a key component of the SWI/SNF chromatin remodeling complex, which has been identified in various cancers. Loss of ARID1A expression is correlated with poor prognosis in gastric cancer (GC); however, the clinical relevance of ARID1A mutations in GC has not yet been reported.
Materials and Methods: A total of 518 GC patients receiving gastrectomy were enrolled. The analysis of 13 mutations of the ARID1A gene using mass spectrometric single-nucleotide polymorphism genotyping technology was conducted. The clinicopathological features of GC with and without ARID1A mutations were compared.
Results: Among the 518 GC patients, 59 (11.4%) had ARID1A mutations. For diffuse-type GC, patients with ARID1A-mutated tumors were older and had fewer poorly differentiated tumors, fewer incidence of Epstein–Barr virus infection, a higher likelihood of ARID1A expression loss, more microsatellite instability-high tumors, a lower prevalence of peritoneal recurrence, and better survival rates than those with ARID1A nonmutant tumors. For intestinal-type GC, patients with ARID1A-mutant tumors had more PI3K/AKT pathway genetic mutations than patients with ARID1A nonmutant tumors. Multivariate analysis showed that ARID1A mutations are an independent prognostic factor in diffuse-type GC.
Conclusion: ARID1A mutations are associated with a better prognosis in diffuse-type GC. |
| first_indexed | 2024-03-12T07:56:23Z |
| format | Article |
| id | doaj.art-ec173d65914c4cb3973a12cac4b1fdea |
| institution | Directory Open Access Journal |
| issn | 1682-606X |
| language | English |
| last_indexed | 2024-03-12T07:56:23Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Formosan Journal of Surgery |
| spelling | doaj.art-ec173d65914c4cb3973a12cac4b1fdea2023-09-02T20:15:32ZengWolters Kluwer Health/LWWFormosan Journal of Surgery1682-606X2020-01-015339310010.4103/fjs.fjs_66_19The clinical significance of ARID1A mutations in gastric cancer patientsChia-Hung WuChien-Hsun TsengKuo-Hung HuangWen-Liang FangMing-Huang ChenAnna Fen-Yau LiChew-Wun WuBackground: ARID1A is a key component of the SWI/SNF chromatin remodeling complex, which has been identified in various cancers. Loss of ARID1A expression is correlated with poor prognosis in gastric cancer (GC); however, the clinical relevance of ARID1A mutations in GC has not yet been reported. Materials and Methods: A total of 518 GC patients receiving gastrectomy were enrolled. The analysis of 13 mutations of the ARID1A gene using mass spectrometric single-nucleotide polymorphism genotyping technology was conducted. The clinicopathological features of GC with and without ARID1A mutations were compared. Results: Among the 518 GC patients, 59 (11.4%) had ARID1A mutations. For diffuse-type GC, patients with ARID1A-mutated tumors were older and had fewer poorly differentiated tumors, fewer incidence of Epstein–Barr virus infection, a higher likelihood of ARID1A expression loss, more microsatellite instability-high tumors, a lower prevalence of peritoneal recurrence, and better survival rates than those with ARID1A nonmutant tumors. For intestinal-type GC, patients with ARID1A-mutant tumors had more PI3K/AKT pathway genetic mutations than patients with ARID1A nonmutant tumors. Multivariate analysis showed that ARID1A mutations are an independent prognostic factor in diffuse-type GC. Conclusion: ARID1A mutations are associated with a better prognosis in diffuse-type GC.http://www.e-fjs.org/article.asp?issn=1682-606X;year=2020;volume=53;issue=3;spage=93;epage=100;aulast=Wuarid1a expressionarid1a mutation diffuse-typegastric cancerprognostic factor |
| spellingShingle | Chia-Hung Wu Chien-Hsun Tseng Kuo-Hung Huang Wen-Liang Fang Ming-Huang Chen Anna Fen-Yau Li Chew-Wun Wu The clinical significance of ARID1A mutations in gastric cancer patients Formosan Journal of Surgery arid1a expression arid1a mutation diffuse-type gastric cancer prognostic factor |
| title | The clinical significance of ARID1A mutations in gastric cancer patients |
| title_full | The clinical significance of ARID1A mutations in gastric cancer patients |
| title_fullStr | The clinical significance of ARID1A mutations in gastric cancer patients |
| title_full_unstemmed | The clinical significance of ARID1A mutations in gastric cancer patients |
| title_short | The clinical significance of ARID1A mutations in gastric cancer patients |
| title_sort | clinical significance of arid1a mutations in gastric cancer patients |
| topic | arid1a expression arid1a mutation diffuse-type gastric cancer prognostic factor |
| url | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2020;volume=53;issue=3;spage=93;epage=100;aulast=Wu |
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