Subcellular Targeting of Theranostic Radionuclides
The last decade has seen rapid growth in the use of theranostic radionuclides for the treatment and imaging of a wide range of cancers. Radionuclide therapy and imaging rely on a radiolabeled vector to specifically target cancer cells. Radionuclides that emit β particles have thus far dominated the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00996/full |
| _version_ | 1818132795251228672 |
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| author | Bas M. Bavelaar Boon Q. Lee Martin R. Gill Nadia Falzone Katherine A. Vallis |
| author_facet | Bas M. Bavelaar Boon Q. Lee Martin R. Gill Nadia Falzone Katherine A. Vallis |
| author_sort | Bas M. Bavelaar |
| collection | DOAJ |
| description | The last decade has seen rapid growth in the use of theranostic radionuclides for the treatment and imaging of a wide range of cancers. Radionuclide therapy and imaging rely on a radiolabeled vector to specifically target cancer cells. Radionuclides that emit β particles have thus far dominated the field of targeted radionuclide therapy (TRT), mainly because the longer range (μm–mm track length) of these particles offsets the heterogeneous expression of the molecular target. Shorter range (nm–μm track length) α- and Auger electron (AE)-emitting radionuclides on the other hand provide high ionization densities at the site of decay which could overcome much of the toxicity associated with β-emitters. Given that there is a growing body of evidence that other sensitive sites besides the DNA, such as the cell membrane and mitochondria, could be critical targets in TRT, improved techniques in detecting the subcellular distribution of these radionuclides are necessary, especially since many β-emitting radionuclides also emit AE. The successful development of TRT agents capable of homing to targets with subcellular precision demands the parallel development of quantitative assays for evaluation of spatial distribution of radionuclides in the nm–μm range. In this review, the status of research directed at subcellular targeting of radionuclide theranostics and the methods for imaging and quantification of radionuclide localization at the nanoscale are described. |
| first_indexed | 2024-12-11T08:42:30Z |
| format | Article |
| id | doaj.art-ec1945208c5043c9a55d886982c00631 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T08:42:30Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ec1945208c5043c9a55d886982c006312022-12-22T01:14:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-09-01910.3389/fphar.2018.00996410789Subcellular Targeting of Theranostic RadionuclidesBas M. BavelaarBoon Q. LeeMartin R. GillNadia FalzoneKatherine A. VallisThe last decade has seen rapid growth in the use of theranostic radionuclides for the treatment and imaging of a wide range of cancers. Radionuclide therapy and imaging rely on a radiolabeled vector to specifically target cancer cells. Radionuclides that emit β particles have thus far dominated the field of targeted radionuclide therapy (TRT), mainly because the longer range (μm–mm track length) of these particles offsets the heterogeneous expression of the molecular target. Shorter range (nm–μm track length) α- and Auger electron (AE)-emitting radionuclides on the other hand provide high ionization densities at the site of decay which could overcome much of the toxicity associated with β-emitters. Given that there is a growing body of evidence that other sensitive sites besides the DNA, such as the cell membrane and mitochondria, could be critical targets in TRT, improved techniques in detecting the subcellular distribution of these radionuclides are necessary, especially since many β-emitting radionuclides also emit AE. The successful development of TRT agents capable of homing to targets with subcellular precision demands the parallel development of quantitative assays for evaluation of spatial distribution of radionuclides in the nm–μm range. In this review, the status of research directed at subcellular targeting of radionuclide theranostics and the methods for imaging and quantification of radionuclide localization at the nanoscale are described.https://www.frontiersin.org/article/10.3389/fphar.2018.00996/fullsubcellular targetingradioimmunotherapytargeted radionuclide therapyradiopharmaceuticalscancerdosimetry |
| spellingShingle | Bas M. Bavelaar Boon Q. Lee Martin R. Gill Nadia Falzone Katherine A. Vallis Subcellular Targeting of Theranostic Radionuclides Frontiers in Pharmacology subcellular targeting radioimmunotherapy targeted radionuclide therapy radiopharmaceuticals cancer dosimetry |
| title | Subcellular Targeting of Theranostic Radionuclides |
| title_full | Subcellular Targeting of Theranostic Radionuclides |
| title_fullStr | Subcellular Targeting of Theranostic Radionuclides |
| title_full_unstemmed | Subcellular Targeting of Theranostic Radionuclides |
| title_short | Subcellular Targeting of Theranostic Radionuclides |
| title_sort | subcellular targeting of theranostic radionuclides |
| topic | subcellular targeting radioimmunotherapy targeted radionuclide therapy radiopharmaceuticals cancer dosimetry |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.00996/full |
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