A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction
Prior computational and imaging studies described changes in flow patterns for patients with Marfan syndrome, but studies are lacking for related populations. This pilot study addresses this void by characterizing wall shear stress (WSS) indices for patients with Loeys-Dietz and undifferentiated con...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.772142/full |
| _version_ | 1818541474012200960 |
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| author | Joseph A. Camarda Ronak J. Dholakia Hongfeng Wang Margaret M. Samyn Margaret M. Samyn Joseph R. Cava John F. LaDisa John F. LaDisa John F. LaDisa |
| author_facet | Joseph A. Camarda Ronak J. Dholakia Hongfeng Wang Margaret M. Samyn Margaret M. Samyn Joseph R. Cava John F. LaDisa John F. LaDisa John F. LaDisa |
| author_sort | Joseph A. Camarda |
| collection | DOAJ |
| description | Prior computational and imaging studies described changes in flow patterns for patients with Marfan syndrome, but studies are lacking for related populations. This pilot study addresses this void by characterizing wall shear stress (WSS) indices for patients with Loeys-Dietz and undifferentiated connective tissue diseases. Using aortic valve-based velocity profiles from magnetic resonance imaging as input to patient-specific fluid structure interaction (FSI) models, we determined local flow patterns throughout the aorta for four patients with various connective tissue diseases (Loeys-Dietz with the native aorta, connective tissue disease of unclear etiology with native aorta in female and male patients, and an untreated patient with Marfan syndrome, as well as twin patients with Marfan syndrome who underwent valve-sparing root replacement). FSI simulations used physiological boundary conditions and material properties to replicate available measurements. Time-averaged WSS (TAWSS) and oscillatory shear index (OSI) results are presented with localized comparison to age- and gender-matched control participants. Ascending aortic dimensions were greater in almost all patients with connective tissue diseases relative to their respective control. Differences in TAWSS and OSI were driven by local morphological differences and cardiac output. For example, the model for one twin had a more pronounced proximal descending aorta in the vicinity of the ductus ligamentum that impacted WSS indices relative to the other. We are optimistic that the results of this study can serve as a foundation for larger future studies on the connective tissue disorders presented in this article. |
| first_indexed | 2024-12-11T22:09:45Z |
| format | Article |
| id | doaj.art-ec1a1b4201304e0caf1dfc2ee6f379f7 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T22:09:45Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ec1a1b4201304e0caf1dfc2ee6f379f72022-12-22T00:48:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-05-011010.3389/fped.2022.772142772142A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure InteractionJoseph A. Camarda0Ronak J. Dholakia1Hongfeng Wang2Margaret M. Samyn3Margaret M. Samyn4Joseph R. Cava5John F. LaDisa6John F. LaDisa7John F. LaDisa8Department of Pediatrics, Division of Cardiology, Herma Heart Institute, Children's Wisconsin and the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Biomedical Engineering, Marquette University the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Biomedical Engineering, Marquette University the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Pediatrics, Division of Cardiology, Herma Heart Institute, Children's Wisconsin and the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Biomedical Engineering, Marquette University the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Pediatrics, Division of Cardiology, Herma Heart Institute, Children's Wisconsin and the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Pediatrics, Division of Cardiology, Herma Heart Institute, Children's Wisconsin and the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Biomedical Engineering, Marquette University the Medical College of Wisconsin, Milwaukee, WI, United StatesDepartments of Medicine, Division of Cardiovascular Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI, United StatesPrior computational and imaging studies described changes in flow patterns for patients with Marfan syndrome, but studies are lacking for related populations. This pilot study addresses this void by characterizing wall shear stress (WSS) indices for patients with Loeys-Dietz and undifferentiated connective tissue diseases. Using aortic valve-based velocity profiles from magnetic resonance imaging as input to patient-specific fluid structure interaction (FSI) models, we determined local flow patterns throughout the aorta for four patients with various connective tissue diseases (Loeys-Dietz with the native aorta, connective tissue disease of unclear etiology with native aorta in female and male patients, and an untreated patient with Marfan syndrome, as well as twin patients with Marfan syndrome who underwent valve-sparing root replacement). FSI simulations used physiological boundary conditions and material properties to replicate available measurements. Time-averaged WSS (TAWSS) and oscillatory shear index (OSI) results are presented with localized comparison to age- and gender-matched control participants. Ascending aortic dimensions were greater in almost all patients with connective tissue diseases relative to their respective control. Differences in TAWSS and OSI were driven by local morphological differences and cardiac output. For example, the model for one twin had a more pronounced proximal descending aorta in the vicinity of the ductus ligamentum that impacted WSS indices relative to the other. We are optimistic that the results of this study can serve as a foundation for larger future studies on the connective tissue disorders presented in this article.https://www.frontiersin.org/articles/10.3389/fped.2022.772142/fullMarfan syndromecomputational modelingpatient-specific modelingwall shear stressLoeys-Dietz syndrome |
| spellingShingle | Joseph A. Camarda Ronak J. Dholakia Hongfeng Wang Margaret M. Samyn Margaret M. Samyn Joseph R. Cava John F. LaDisa John F. LaDisa John F. LaDisa A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction Frontiers in Pediatrics Marfan syndrome computational modeling patient-specific modeling wall shear stress Loeys-Dietz syndrome |
| title | A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction |
| title_full | A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction |
| title_fullStr | A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction |
| title_full_unstemmed | A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction |
| title_short | A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched Controls via Fluid Structure Interaction |
| title_sort | pilot study characterizing flow patterns in the thoracic aorta of patients with connective tissue disease comparison to age and gender matched controls via fluid structure interaction |
| topic | Marfan syndrome computational modeling patient-specific modeling wall shear stress Loeys-Dietz syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.772142/full |
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