Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury

Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury

Mitophagy is a crucial process in controlling mitochondrial biogenesis. Balancing mitophagy and mitochondrial functions is required for maintaining cellular homeostasis. In this study, we found that Gerontoxanthone I (GeX1) and Macluraxanthone (McX), xanthone derivatives isolated from Garcinia bract...

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Bibliographic Details
Main Authors: Qian Xiang, Man Wu, Li Zhang, Wenwei Fu, Jinling Yang, Baojun Zhang, Zhaoqing Zheng, Hong Zhang, Yuanzhi Lao, Hongxi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
mitophagy
PINK1-Parkin pathway
Gerontoxanthone I
Macluraxanthone
ischemia/reperfusion injury
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00452/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00452/full

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