In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp.
Candida species are the most common cause of opportunistic fungal infection worldwide. Due to increasing resistance of fungi against conventional drugs, as well as their side effects, alternative natural products have become a renewed interest. In the current study, the anti-Candida activities of Sc...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2016-01-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-77-2&slc_lang=en&sid=1 |
| _version_ | 1819263850286940160 |
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| author | Mandana Ahmadi Hossein Mahdavi Mahboobeh Madani Zohreh Hadadi |
| author_facet | Mandana Ahmadi Hossein Mahdavi Mahboobeh Madani Zohreh Hadadi |
| author_sort | Mandana Ahmadi |
| collection | DOAJ |
| description | Candida species are the most common cause of opportunistic fungal infection worldwide. Due to increasing resistance of fungi against conventional drugs, as well as their side effects, alternative natural products have become a renewed interest. In the current study, the anti-Candida activities of Scrophularia striata extract were examined. In this experimental study, microdilution assay and well diffusion test were used to determine invitro anti-fungal effects of ethanolic and methanolic extract of Scrophulari astriata on four species of Candida including Candida albicans ATCC 1167, ATCC 1677, tropicalis, and glabrata. The results showed that 100 mg/ml methanolic extract has more anticandida activity than ethanolic extract. Diameter of inhibiting growth environment for ethanol extract was 37 mm, and MIC and MFC were 2.1 and 41.5 mm/ml. Results show that ethanolic and methanolic extract of Scrophularia striata have anti-fungal activities. Therefore results of this study suggest this extract is a promising anti-fungal agent, and future experiments will interest for performing in vivo study. |
| first_indexed | 2024-12-23T20:20:08Z |
| format | Article |
| id | doaj.art-ec1ae542ddc545f4803a6088c06a5b5d |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-23T20:20:08Z |
| publishDate | 2016-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-ec1ae542ddc545f4803a6088c06a5b5d2022-12-21T17:32:34ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942016-01-01243843In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp.Mandana Ahmadi0Hossein Mahdavi1Mahboobeh Madani2Zohreh Hadadi3 Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran Department of Microbiology, Falavarjan Branch,Islamic Azad University, Isfahan, Iran Research and Development Department, Sinafaravar pharmaceutical Company, Najaf abad, Isfahan, Iran Candida species are the most common cause of opportunistic fungal infection worldwide. Due to increasing resistance of fungi against conventional drugs, as well as their side effects, alternative natural products have become a renewed interest. In the current study, the anti-Candida activities of Scrophularia striata extract were examined. In this experimental study, microdilution assay and well diffusion test were used to determine invitro anti-fungal effects of ethanolic and methanolic extract of Scrophulari astriata on four species of Candida including Candida albicans ATCC 1167, ATCC 1677, tropicalis, and glabrata. The results showed that 100 mg/ml methanolic extract has more anticandida activity than ethanolic extract. Diameter of inhibiting growth environment for ethanol extract was 37 mm, and MIC and MFC were 2.1 and 41.5 mm/ml. Results show that ethanolic and methanolic extract of Scrophularia striata have anti-fungal activities. Therefore results of this study suggest this extract is a promising anti-fungal agent, and future experiments will interest for performing in vivo study.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-77-2&slc_lang=en&sid=1Scrophulariastriata Candida ehanolic extract methanolic extract |
| spellingShingle | Mandana Ahmadi Hossein Mahdavi Mahboobeh Madani Zohreh Hadadi In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. Pharmaceutical and Biomedical Research Scrophulariastriata Candida ehanolic extract methanolic extract |
| title | In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. |
| title_full | In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. |
| title_fullStr | In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. |
| title_full_unstemmed | In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. |
| title_short | In-vitro inhibitory effect of ethanolic and methanolic extract of Scrophulari astriata on Candida spp. |
| title_sort | in vitro inhibitory effect of ethanolic and methanolic extract of scrophulari astriata on candida spp |
| topic | Scrophulariastriata Candida ehanolic extract methanolic extract |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-77-2&slc_lang=en&sid=1 |
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