Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice
Abstract Biliary tract cancer (BTC) that contains cholangiocarcinoma, gallbladder cancer, and ampullary cancer is highly malignant and mostly diagnosed in elderly patients. Over the past decades, human life has globally risen; thus, aging emerges as the primary risk factor for BTC. However, an effec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | Aging and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aac2.12054 |
| _version_ | 1811294713657950208 |
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| author | Xiaoling Weng Xiaoling Song Rong Shao Fatao Liu Yingbin Liu |
| author_facet | Xiaoling Weng Xiaoling Song Rong Shao Fatao Liu Yingbin Liu |
| author_sort | Xiaoling Weng |
| collection | DOAJ |
| description | Abstract Biliary tract cancer (BTC) that contains cholangiocarcinoma, gallbladder cancer, and ampullary cancer is highly malignant and mostly diagnosed in elderly patients. Over the past decades, human life has globally risen; thus, aging emerges as the primary risk factor for BTC. However, an effective treatment for this vulnerable population remains a large clinical challenge. As a result, the incidence and mortality of TBC remains high. Here, we discuss the potential link between aging and BTC from the aspects of molecular and cellular mechanisms, surgical resection, and chemotherapy. In addition, we update a number of clinical trials that are currently ongoing in elderly patients. The overview of BTC in elderly patients is expected to help develop a new therapeutic strategy tailored to this elderly population, ultimately improving their life quality. |
| first_indexed | 2024-04-13T05:21:33Z |
| format | Article |
| id | doaj.art-ec1b59e7906241a68d795bc0c0583216 |
| institution | Directory Open Access Journal |
| issn | 2643-8909 |
| language | English |
| last_indexed | 2024-04-13T05:21:33Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging and Cancer |
| spelling | doaj.art-ec1b59e7906241a68d795bc0c05832162022-12-22T03:00:44ZengWileyAging and Cancer2643-89092022-06-01329510410.1002/aac2.12054Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practiceXiaoling Weng0Xiaoling Song1Rong Shao2Fatao Liu3Yingbin Liu4State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaShanghai Key Laboratory of Biliary Tract Disease Research Shanghai ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaAbstract Biliary tract cancer (BTC) that contains cholangiocarcinoma, gallbladder cancer, and ampullary cancer is highly malignant and mostly diagnosed in elderly patients. Over the past decades, human life has globally risen; thus, aging emerges as the primary risk factor for BTC. However, an effective treatment for this vulnerable population remains a large clinical challenge. As a result, the incidence and mortality of TBC remains high. Here, we discuss the potential link between aging and BTC from the aspects of molecular and cellular mechanisms, surgical resection, and chemotherapy. In addition, we update a number of clinical trials that are currently ongoing in elderly patients. The overview of BTC in elderly patients is expected to help develop a new therapeutic strategy tailored to this elderly population, ultimately improving their life quality.https://doi.org/10.1002/aac2.12054agingbiliary tract cancermicroenvironmentsenescencetherapy |
| spellingShingle | Xiaoling Weng Xiaoling Song Rong Shao Fatao Liu Yingbin Liu Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice Aging and Cancer aging biliary tract cancer microenvironment senescence therapy |
| title | Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice |
| title_full | Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice |
| title_fullStr | Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice |
| title_full_unstemmed | Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice |
| title_short | Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice |
| title_sort | aging and biliary tract cancers epidemiology molecular biology and clinical practice |
| topic | aging biliary tract cancer microenvironment senescence therapy |
| url | https://doi.org/10.1002/aac2.12054 |
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