Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity
Background Obesity is a risk factor for obesity-related disorders such as type 2 diabetes mellitus, vascular disease, osteoarthritis, sleep apnea, and malignancy. Obesity cohinder the individual work capacity, and the cost for managing obesity complications is high. Objective The objective of this r...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Al-Azhar Assiut Medical Journal |
| Subjects: | |
| Online Access: | http://www.azmj.eg.net/article.asp?issn=1687-1693;year=2016;volume=14;issue=3;spage=101;epage=108;aulast=Mahmoud |
| _version_ | 1829143752516567040 |
|---|---|
| author | Ahmed Mostafa Mahmoud |
| author_facet | Ahmed Mostafa Mahmoud |
| author_sort | Ahmed Mostafa Mahmoud |
| collection | DOAJ |
| description | Background
Obesity is a risk factor for obesity-related disorders such as type 2 diabetes mellitus, vascular disease, osteoarthritis, sleep apnea, and malignancy. Obesity cohinder the individual work capacity, and the cost for managing obesity complications is high.
Objective
The objective of this research was to study the role of pancreatic polypeptide family including neuropeptide Y and peptide tyrosine tyrosine (PYY) in obesity development and its metabolic changes.
Materials and methods
Twenty-seven adult female albino rats of a local strain were randomized into three equal groups for 5 weeks: sham-operated group, ovariectomized nontreated group, and ovariectomized treated group received PYY3–36 at a dose of 50 μg/kg, by intraperitoneal injection twice daily during the fifth week.
Results
Peripheral PYY3–36 administration reduces food intake, body weight gain, and serum glucose in ovariectomized obese female rats.
Conclusion
PYY system may offer a new therapeutic strategy for obesity management and its metabolic abnormalities. |
| first_indexed | 2024-12-14T20:55:46Z |
| format | Article |
| id | doaj.art-ec1c43d73d0b42e9a07b37071d0ac5ab |
| institution | Directory Open Access Journal |
| issn | 1687-1693 |
| language | English |
| last_indexed | 2024-12-14T20:55:46Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Al-Azhar Assiut Medical Journal |
| spelling | doaj.art-ec1c43d73d0b42e9a07b37071d0ac5ab2022-12-21T22:47:42ZengWolters Kluwer Medknow PublicationsAl-Azhar Assiut Medical Journal1687-16932016-01-0114310110810.4103/1687-1693.200146Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesityAhmed Mostafa MahmoudBackground Obesity is a risk factor for obesity-related disorders such as type 2 diabetes mellitus, vascular disease, osteoarthritis, sleep apnea, and malignancy. Obesity cohinder the individual work capacity, and the cost for managing obesity complications is high. Objective The objective of this research was to study the role of pancreatic polypeptide family including neuropeptide Y and peptide tyrosine tyrosine (PYY) in obesity development and its metabolic changes. Materials and methods Twenty-seven adult female albino rats of a local strain were randomized into three equal groups for 5 weeks: sham-operated group, ovariectomized nontreated group, and ovariectomized treated group received PYY3–36 at a dose of 50 μg/kg, by intraperitoneal injection twice daily during the fifth week. Results Peripheral PYY3–36 administration reduces food intake, body weight gain, and serum glucose in ovariectomized obese female rats. Conclusion PYY system may offer a new therapeutic strategy for obesity management and its metabolic abnormalities.http://www.azmj.eg.net/article.asp?issn=1687-1693;year=2016;volume=14;issue=3;spage=101;epage=108;aulast=Mahmoudmetabolic diseaseobesityovariectomized ratspancreatic polypeptidespeptide tyrosine tyrosine |
| spellingShingle | Ahmed Mostafa Mahmoud Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity Al-Azhar Assiut Medical Journal metabolic disease obesity ovariectomized rats pancreatic polypeptides peptide tyrosine tyrosine |
| title | Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity |
| title_full | Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity |
| title_fullStr | Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity |
| title_full_unstemmed | Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity |
| title_short | Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity |
| title_sort | peptide tyrosine tyrosine pyy as a new strategy for treating obesity |
| topic | metabolic disease obesity ovariectomized rats pancreatic polypeptides peptide tyrosine tyrosine |
| url | http://www.azmj.eg.net/article.asp?issn=1687-1693;year=2016;volume=14;issue=3;spage=101;epage=108;aulast=Mahmoud |
| work_keys_str_mv | AT ahmedmostafamahmoud peptidetyrosinetyrosinepyyasanewstrategyfortreatingobesity |