The relationship between isolated hypertension with brain volumes in UK Biobank
Abstract Background Hypertension is a well‐established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types of hypertensions, such as isolated hypertension on brain health and its comparison to systolic‐diastolic hypertension (where systolic and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2525 |
| _version_ | 1797737320774893568 |
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| author | Danielle Newby Laura Winchester William Sproviero Marco Fernandes Upamanyu Ghose Donald Lyall Lenore J. Launer Alejo J. Nevado‐Holgado |
| author_facet | Danielle Newby Laura Winchester William Sproviero Marco Fernandes Upamanyu Ghose Donald Lyall Lenore J. Launer Alejo J. Nevado‐Holgado |
| author_sort | Danielle Newby |
| collection | DOAJ |
| description | Abstract Background Hypertension is a well‐established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types of hypertensions, such as isolated hypertension on brain health and its comparison to systolic‐diastolic hypertension (where systolic and diastolic measures are high), is still relatively unknown. Due to its increased prevalence, it is important to investigate the impact of isolated hypertension to help understand its potential impact on cognitive decline and future dementia risk. In this study, we compared a variety of global brain measures between participants with isolated hypertension to those with normal blood pressure (BP) or systolic‐diastolic hypertension using the largest cohort of healthy individuals. Methods Using the UK Biobank cohort, we carried out a cross‐sectional study using 29,775 participants (mean age 63 years, 53% female) with BP measurements and brain magnetic resonance imaging (MRI) data. We used linear regression models adjusted for multiple confounders to compare a variety of global, subcortical, and white matter brain measures. We compared participants with either isolated systolic or diastolic hypertension with normotensives and then with participants with systolic‐diastolic hypertension. Results The results showed that participants with isolated systolic or diastolic hypertension taking BP medications had smaller gray matter but larger white matter microstructures and macrostructures compared to normotensives. Isolated systolic hypertensives had larger total gray matter and smaller white matter traits when comparing these regions with participants with systolic‐diastolic hypertension. Conclusions These results provide support to investigate possible preventative strategies that target isolated hypertension as well as systolic‐diastolic hypertension to maintain brain health and/or reduce dementia risk earlier in life particularly in white matter regions. |
| first_indexed | 2024-03-12T13:26:58Z |
| format | Article |
| id | doaj.art-ec1c5418840847ddac407608392adc99 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T13:26:58Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-ec1c5418840847ddac407608392adc992023-08-25T04:42:55ZengWileyBrain and Behavior2162-32792022-05-01125n/an/a10.1002/brb3.2525The relationship between isolated hypertension with brain volumes in UK BiobankDanielle Newby0Laura Winchester1William Sproviero2Marco Fernandes3Upamanyu Ghose4Donald Lyall5Lenore J. Launer6Alejo J. Nevado‐Holgado7Department of Psychiatry Warneford Hospital, University of Oxford Oxford UKDepartment of Psychiatry Warneford Hospital, University of Oxford Oxford UKDepartment of Psychiatry Warneford Hospital, University of Oxford Oxford UKDepartment of Psychiatry Warneford Hospital, University of Oxford Oxford UKDepartment of Psychiatry Warneford Hospital, University of Oxford Oxford UKInstitute of Health and Wellbeing University of Glasgow Scotland UKNational Institute on Aging Bethesda Maryland USADepartment of Psychiatry Warneford Hospital, University of Oxford Oxford UKAbstract Background Hypertension is a well‐established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types of hypertensions, such as isolated hypertension on brain health and its comparison to systolic‐diastolic hypertension (where systolic and diastolic measures are high), is still relatively unknown. Due to its increased prevalence, it is important to investigate the impact of isolated hypertension to help understand its potential impact on cognitive decline and future dementia risk. In this study, we compared a variety of global brain measures between participants with isolated hypertension to those with normal blood pressure (BP) or systolic‐diastolic hypertension using the largest cohort of healthy individuals. Methods Using the UK Biobank cohort, we carried out a cross‐sectional study using 29,775 participants (mean age 63 years, 53% female) with BP measurements and brain magnetic resonance imaging (MRI) data. We used linear regression models adjusted for multiple confounders to compare a variety of global, subcortical, and white matter brain measures. We compared participants with either isolated systolic or diastolic hypertension with normotensives and then with participants with systolic‐diastolic hypertension. Results The results showed that participants with isolated systolic or diastolic hypertension taking BP medications had smaller gray matter but larger white matter microstructures and macrostructures compared to normotensives. Isolated systolic hypertensives had larger total gray matter and smaller white matter traits when comparing these regions with participants with systolic‐diastolic hypertension. Conclusions These results provide support to investigate possible preventative strategies that target isolated hypertension as well as systolic‐diastolic hypertension to maintain brain health and/or reduce dementia risk earlier in life particularly in white matter regions.https://doi.org/10.1002/brb3.2525brain healthhypertensionisolated hypertension |
| spellingShingle | Danielle Newby Laura Winchester William Sproviero Marco Fernandes Upamanyu Ghose Donald Lyall Lenore J. Launer Alejo J. Nevado‐Holgado The relationship between isolated hypertension with brain volumes in UK Biobank Brain and Behavior brain health hypertension isolated hypertension |
| title | The relationship between isolated hypertension with brain volumes in UK Biobank |
| title_full | The relationship between isolated hypertension with brain volumes in UK Biobank |
| title_fullStr | The relationship between isolated hypertension with brain volumes in UK Biobank |
| title_full_unstemmed | The relationship between isolated hypertension with brain volumes in UK Biobank |
| title_short | The relationship between isolated hypertension with brain volumes in UK Biobank |
| title_sort | relationship between isolated hypertension with brain volumes in uk biobank |
| topic | brain health hypertension isolated hypertension |
| url | https://doi.org/10.1002/brb3.2525 |
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