АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and grou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2015-03-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/811 |
| _version_ | 1826534231880237056 |
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| author | S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov |
| author_facet | S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov |
| author_sort | S. N. Skorniakov |
| collection | DOAJ |
| description | The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and group 3, 27 patients with fibrous/cavernous tuberculosis for less than two years after the process stabilization. Group 4 represented a control (comparison) group of 30 healthy volunteers. The analysis showed that amino acid balance of monocytes in pulmonary tuberculosis can be, in general, characterized as deficient for antioxidant resources. In case of tuberculous inflammation, the criteria of specific resistance comprise a necessary taurine pool to greater extent than glutathione oxidation in immunocompetent cells. The plasma/monocyte taurine ratios exhibit different values, depending on clinical form of pulmonary tuberculosis. Redistribution of plasma amino acids to the monocytes, or, vice versa, probable “washout” certain amino acids from the cells may be considered a factor that reflects severity of the infectious process. |
| first_indexed | 2024-03-08T05:50:12Z |
| format | Article |
| id | doaj.art-ec1c5eb183e6415e8b59d3e84da4e6bd |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:19:44Z |
| publishDate | 2015-03-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-ec1c5eb183e6415e8b59d3e84da4e6bd2025-03-11T17:59:06ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2015-03-01171758010.15789/1563-0625-2015-1-75-80736АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSISS. N. Skorniakov0E. V. Sabadash1I. D. Medvinsky2B. I. Novikov3V. A. Pavlov4Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care 620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care 620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care 620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care 620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care 620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and group 3, 27 patients with fibrous/cavernous tuberculosis for less than two years after the process stabilization. Group 4 represented a control (comparison) group of 30 healthy volunteers. The analysis showed that amino acid balance of monocytes in pulmonary tuberculosis can be, in general, characterized as deficient for antioxidant resources. In case of tuberculous inflammation, the criteria of specific resistance comprise a necessary taurine pool to greater extent than glutathione oxidation in immunocompetent cells. The plasma/monocyte taurine ratios exhibit different values, depending on clinical form of pulmonary tuberculosis. Redistribution of plasma amino acids to the monocytes, or, vice versa, probable “washout” certain amino acids from the cells may be considered a factor that reflects severity of the infectious process.https://www.mimmun.ru/mimmun/article/view/811amino acidstaurineglutathionemonocytespulmonary tuberculosis |
| spellingShingle | S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS Медицинская иммунология amino acids taurine glutathione monocytes pulmonary tuberculosis |
| title | АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS |
| title_full | АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS |
| title_fullStr | АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS |
| title_full_unstemmed | АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS |
| title_short | АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS |
| title_sort | аmino acid balance plasma and monocytes in patients with tuberculosis as a factor reflects the severity of development of tuberculosis |
| topic | amino acids taurine glutathione monocytes pulmonary tuberculosis |
| url | https://www.mimmun.ru/mimmun/article/view/811 |
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