Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome

Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome

Dravet syndrome is a type of severe childhood epilepsy that responds poorly to current anti-epileptic drugs. In recent years, zebrafish disease models with Scn1Lab sodium channel deficiency have been generated to seek novel anti-epileptic drug candidates, some of which are currently undergoing clini...

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Bibliographic Details
Main Authors: Alexandre Brenet, Rahma Hassan-Abdi, Julie Somkhit, Constantin Yanicostas, Nadia Soussi-Yanicostas
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
dravet syndrome
calcium imaging
local field potential
excitatory/inhibitory balance
apoptosis
in vivo imaging
zebrafish
<i>scn1lab</i>
morpholino scn1lab<sup>aug</sup>
Online Access:https://www.mdpi.com/2073-4409/8/10/1199

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