Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study
Abstract Background Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period. Methods We enrolled patients with...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12378 |
| _version_ | 1797263703447437312 |
|---|---|
| author | Yasushi Kawamata Norio Sugawara Taro Sasaki Saaya Yokoyama Hiroaki Okayasu Masataka Shinozaki Yoshitaka Takeuchi Aoi Sato Takaaki Ishikawa Hazuki Komahashi‐Sasaki Kensuke Miyazaki Takashi Fukasawa Hanako Furukori Norio Yasui‐Furukori |
| author_facet | Yasushi Kawamata Norio Sugawara Taro Sasaki Saaya Yokoyama Hiroaki Okayasu Masataka Shinozaki Yoshitaka Takeuchi Aoi Sato Takaaki Ishikawa Hazuki Komahashi‐Sasaki Kensuke Miyazaki Takashi Fukasawa Hanako Furukori Norio Yasui‐Furukori |
| author_sort | Yasushi Kawamata |
| collection | DOAJ |
| description | Abstract Background Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period. Methods We enrolled patients with schizophrenia attending each hospital (n = 14) from April 1, 2021, and retrospectively examined all prescriptions as of April 1, 2016, 2011, 2006, and 2001, every 5 years starting in 2021, for this population. 716 participants with complete data were included in the analysis. The Cochran Q test followed by Bonferroni correction and the Cochran–Armitage trend test were used to determine the differences and trends of the frequency of each laxative. Multivariate logistic regression analysis was performed to assess the factors on the initiation of laxative use over a 20‐year period. Results Of the patients, 25.1% were treated with laxatives in 2001, and 34.1% were treated in 2021. The numbers of patients treated with any laxatives significantly differed over the 20‐year period, with a significant increasing trend. In all laxatives, the numbers of patients treated with magnesium oxide, lubiprostone and elobixibat differed with a significant increasing trend. Female sex, age, the total DZP equivalent dose, and the doses of levomepromazine maleate, olanzapine, quetiapine, zotepine, lithium, and carbamazepine in 2021 were significant factors associated with the initiation of laxative use over the 20‐year period. Conclusions Careful monitoring is needed for patients treated with levomepromazine maleate, olanzapine, quetiapine and zotepine. Optimizing prescriptions according to treatment guidelines could reduce antipsychotic‐induced constipation. |
| first_indexed | 2024-04-25T00:17:13Z |
| format | Article |
| id | doaj.art-ec1dfed344cf4c0f90b7ba30e00897f2 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-25T00:17:13Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-ec1dfed344cf4c0f90b7ba30e00897f22024-03-13T03:12:13ZengWileyNeuropsychopharmacology Reports2574-173X2024-03-01441606610.1002/npr2.12378Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort studyYasushi Kawamata0Norio Sugawara1Taro Sasaki2Saaya Yokoyama3Hiroaki Okayasu4Masataka Shinozaki5Yoshitaka Takeuchi6Aoi Sato7Takaaki Ishikawa8Hazuki Komahashi‐Sasaki9Kensuke Miyazaki10Takashi Fukasawa11Hanako Furukori12Norio Yasui‐Furukori13Department of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanDepartment of Neuropsychiatry Hirosaki‐Aiseikai Hospital Aomori JapanDepartment of Psychiatry Seinan Hospital Aomori JapanDepartment of Neuropsychiatry Kuroichi‐Akebono Hospital Aomori JapanDepartment of Psychiatry, School of Medicine Dokkyo Medical University Tochigi JapanAbstract Background Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period. Methods We enrolled patients with schizophrenia attending each hospital (n = 14) from April 1, 2021, and retrospectively examined all prescriptions as of April 1, 2016, 2011, 2006, and 2001, every 5 years starting in 2021, for this population. 716 participants with complete data were included in the analysis. The Cochran Q test followed by Bonferroni correction and the Cochran–Armitage trend test were used to determine the differences and trends of the frequency of each laxative. Multivariate logistic regression analysis was performed to assess the factors on the initiation of laxative use over a 20‐year period. Results Of the patients, 25.1% were treated with laxatives in 2001, and 34.1% were treated in 2021. The numbers of patients treated with any laxatives significantly differed over the 20‐year period, with a significant increasing trend. In all laxatives, the numbers of patients treated with magnesium oxide, lubiprostone and elobixibat differed with a significant increasing trend. Female sex, age, the total DZP equivalent dose, and the doses of levomepromazine maleate, olanzapine, quetiapine, zotepine, lithium, and carbamazepine in 2021 were significant factors associated with the initiation of laxative use over the 20‐year period. Conclusions Careful monitoring is needed for patients treated with levomepromazine maleate, olanzapine, quetiapine and zotepine. Optimizing prescriptions according to treatment guidelines could reduce antipsychotic‐induced constipation.https://doi.org/10.1002/npr2.12378antipsychoticsconstipationguidelinelaxativemood stabilizeroutpatients |
| spellingShingle | Yasushi Kawamata Norio Sugawara Taro Sasaki Saaya Yokoyama Hiroaki Okayasu Masataka Shinozaki Yoshitaka Takeuchi Aoi Sato Takaaki Ishikawa Hazuki Komahashi‐Sasaki Kensuke Miyazaki Takashi Fukasawa Hanako Furukori Norio Yasui‐Furukori Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study Neuropsychopharmacology Reports antipsychotics constipation guideline laxative mood stabilizer outpatients |
| title | Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study |
| title_full | Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study |
| title_fullStr | Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study |
| title_full_unstemmed | Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study |
| title_short | Factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20‐year period: Retrospective cohort study |
| title_sort | factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20 year period retrospective cohort study |
| topic | antipsychotics constipation guideline laxative mood stabilizer outpatients |
| url | https://doi.org/10.1002/npr2.12378 |
| work_keys_str_mv | AT yasushikawamata factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT noriosugawara factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT tarosasaki factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT saayayokoyama factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT hiroakiokayasu factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT masatakashinozaki factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT yoshitakatakeuchi factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT aoisato factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT takaakiishikawa factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT hazukikomahashisasaki factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT kensukemiyazaki factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT takashifukasawa factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT hanakofurukori factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy AT norioyasuifurukori factorsassociatedwiththeinitiationoflaxativeuseinthesamepatientswithschizophreniaovera20yearperiodretrospectivecohortstudy |