The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction
Aim:The assessment of heart rate variability (HRV) has been considered as an important non-invasive method to evaluate cardiac autonomic function. Concerning recent evidence on the relationship between impaired autonomic dysfunction and sarcoidosis, we aimed to investigate the effect of pulmonary sa...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2021-12-01
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| Series: | Namık Kemal Tıp Dergisi |
| Subjects: | |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effect-of-pulmonary-sarcoidosis-on-cardiac-aut/49754
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| _version_ | 1797921432772018176 |
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| author | Ali MANAV Gökay TAYLAN Meryem AKTOZ |
| author_facet | Ali MANAV Gökay TAYLAN Meryem AKTOZ |
| author_sort | Ali MANAV |
| collection | DOAJ |
| description | Aim:The assessment of heart rate variability (HRV) has been considered as an important non-invasive method to evaluate cardiac autonomic function. Concerning recent evidence on the relationship between impaired autonomic dysfunction and sarcoidosis, we aimed to investigate the effect of pulmonary sarcoidosis on cardiac autonomic dysfunction.Materials and Methods:This prospective study comprised of 36 participants, including 18 patients diagnosed with pulmonary sarcoidosis and 18 age-matched healthy volunteers. All participants underwent echocardiographic examination, 12-channel electrocardiography and 24-h Holter monitoring. HRV parameters were determined and compared between the groups.Results:In time domain analyses, RMSDD values significantly decreased in the patient group compared to the control group (p=0.043). The low-frequency power in frequency domain analyses between sarcoidosis patients and controls demonstrated a statistically significant difference (p=0.045). In the correlation analysis, PR duration was negatively correlated with all-time domain and frequency domain parameters as SDNN, SDANN and high-frequency values, which had a statistically significant difference (p=0.009, p=0.003, p=0.047 respectively). Corrected QT (QTc) duration was negatively correlated with all-time domain and frequency domain parameters as well. The low-frequency/high-frequency ratio was positively correlated with QTc duration.Conclusion:The patients with pulmonary sarcoidosis displayed a decrease in all HRV values reflecting diminished parasympathetic tone or blunted cardiac response to vagal modulation. This may cause cardiac outcomes such as atrioventricular conduction abnormalities, proarrhythmic tendency, ventricular arrhythmias and sudden death. |
| first_indexed | 2024-04-10T14:15:54Z |
| format | Article |
| id | doaj.art-ec1ebd16f58a428fac150b5a3261f465 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T14:15:54Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-ec1ebd16f58a428fac150b5a3261f4652023-02-15T16:09:33ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622021-12-019328428910.4274/nkmj.galenos.2021.2959113049054The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic DysfunctionAli MANAV0Gökay TAYLAN1Meryem AKTOZ2 Lüleburgaz Devlet Hastanesi, Kardiyoloji Kliniği, Kırklareli, Türkiye Trakya Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Edirne, Türkiye Trakya Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Edirne, Türkiye Aim:The assessment of heart rate variability (HRV) has been considered as an important non-invasive method to evaluate cardiac autonomic function. Concerning recent evidence on the relationship between impaired autonomic dysfunction and sarcoidosis, we aimed to investigate the effect of pulmonary sarcoidosis on cardiac autonomic dysfunction.Materials and Methods:This prospective study comprised of 36 participants, including 18 patients diagnosed with pulmonary sarcoidosis and 18 age-matched healthy volunteers. All participants underwent echocardiographic examination, 12-channel electrocardiography and 24-h Holter monitoring. HRV parameters were determined and compared between the groups.Results:In time domain analyses, RMSDD values significantly decreased in the patient group compared to the control group (p=0.043). The low-frequency power in frequency domain analyses between sarcoidosis patients and controls demonstrated a statistically significant difference (p=0.045). In the correlation analysis, PR duration was negatively correlated with all-time domain and frequency domain parameters as SDNN, SDANN and high-frequency values, which had a statistically significant difference (p=0.009, p=0.003, p=0.047 respectively). Corrected QT (QTc) duration was negatively correlated with all-time domain and frequency domain parameters as well. The low-frequency/high-frequency ratio was positively correlated with QTc duration.Conclusion:The patients with pulmonary sarcoidosis displayed a decrease in all HRV values reflecting diminished parasympathetic tone or blunted cardiac response to vagal modulation. This may cause cardiac outcomes such as atrioventricular conduction abnormalities, proarrhythmic tendency, ventricular arrhythmias and sudden death. http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effect-of-pulmonary-sarcoidosis-on-cardiac-aut/49754 heart rate variabilitysarcoidosisautonomic dysfunction |
| spellingShingle | Ali MANAV Gökay TAYLAN Meryem AKTOZ The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction Namık Kemal Tıp Dergisi heart rate variability sarcoidosis autonomic dysfunction |
| title | The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction |
| title_full | The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction |
| title_fullStr | The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction |
| title_full_unstemmed | The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction |
| title_short | The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction |
| title_sort | effect of pulmonary sarcoidosis on cardiac autonomic dysfunction |
| topic | heart rate variability sarcoidosis autonomic dysfunction |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effect-of-pulmonary-sarcoidosis-on-cardiac-aut/49754
|
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