The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle
Background & Objectives: Apoptosis in skeletal muscle plays an important role in disease-related tissue dysfunction such as muscle atrophy. Current evidence suggests that exercise training may alter apoptosis-related signaling and enzymes in skeletal muscle. Therefore, the purpose of this study...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2017-09-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1143-en.pdf |
| _version_ | 1797679661680951296 |
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| author | Neda Abadi Jabbar Bashiri |
| author_facet | Neda Abadi Jabbar Bashiri |
| author_sort | Neda Abadi |
| collection | DOAJ |
| description | Background & Objectives: Apoptosis in skeletal muscle plays an important role in disease-related tissue dysfunction such as muscle atrophy. Current evidence suggests that exercise training may alter apoptosis-related signaling and enzymes in skeletal muscle. Therefore, the purpose of this study was to investigate the effect of three-month aerobic training on AIF and caspase-9 gene expression in male rat soleus muscle.
Materials & Methods: This study was conducted as a two-group experimental design and sixteen 3-month-old male rats were selected and randomly divided into two groups of aerobic training (n=8) and control (n=8). Rats in trained group participated in the aerobic training program for three months (75-80%). 48 hours after the last training session, the soleus muscle of rats were extracted and AIF and caspase-9 mRNA were evaluated by Real Time-PCR. Independent-samples t-test was applied to analyze the data (P<0.05).
Results: AIF gene expression of trained group was significantly higher than that of the control group (137.60%, P=0.01). Furthermore, caspase-9 gene expression of trained group was significantly higher than that of the control group (48.22%, P=0.01).
Conclusion: In general, it seems that a three-month aerobic training was effective in increasing soleus muscle mitochondrial apoptotic protein. However, more research needs to be done to identify the effects of exercise trainings on indices of apoptosis and skeletal muscle atrophy. |
| first_indexed | 2024-03-11T23:18:07Z |
| format | Article |
| id | doaj.art-ec2048e2ac1b468ebd8aae997d0e820b |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:18:07Z |
| publishDate | 2017-09-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-ec2048e2ac1b468ebd8aae997d0e820b2023-09-20T21:23:04ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232017-09-0172257264The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscleNeda Abadi0Jabbar Bashiri1 Tabriz Branch, Islamic Azad University, Tabriz, Iran Tabriz Branch, Islamic Azad University, Tabriz, Iran Background & Objectives: Apoptosis in skeletal muscle plays an important role in disease-related tissue dysfunction such as muscle atrophy. Current evidence suggests that exercise training may alter apoptosis-related signaling and enzymes in skeletal muscle. Therefore, the purpose of this study was to investigate the effect of three-month aerobic training on AIF and caspase-9 gene expression in male rat soleus muscle. Materials & Methods: This study was conducted as a two-group experimental design and sixteen 3-month-old male rats were selected and randomly divided into two groups of aerobic training (n=8) and control (n=8). Rats in trained group participated in the aerobic training program for three months (75-80%). 48 hours after the last training session, the soleus muscle of rats were extracted and AIF and caspase-9 mRNA were evaluated by Real Time-PCR. Independent-samples t-test was applied to analyze the data (P<0.05). Results: AIF gene expression of trained group was significantly higher than that of the control group (137.60%, P=0.01). Furthermore, caspase-9 gene expression of trained group was significantly higher than that of the control group (48.22%, P=0.01). Conclusion: In general, it seems that a three-month aerobic training was effective in increasing soleus muscle mitochondrial apoptotic protein. However, more research needs to be done to identify the effects of exercise trainings on indices of apoptosis and skeletal muscle atrophy.http://jabs.fums.ac.ir/article-1-1143-en.pdfaerobic trainingsoleus muscleaif genecaspase-9 gene |
| spellingShingle | Neda Abadi Jabbar Bashiri The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle Journal of Advanced Biomedical Sciences aerobic training soleus muscle aif gene caspase-9 gene |
| title | The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle |
| title_full | The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle |
| title_fullStr | The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle |
| title_full_unstemmed | The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle |
| title_short | The effect of three-month aerobic training on the expression of AIF and caspase-9 gene in male rat soleus muscle |
| title_sort | effect of three month aerobic training on the expression of aif and caspase 9 gene in male rat soleus muscle |
| topic | aerobic training soleus muscle aif gene caspase-9 gene |
| url | http://jabs.fums.ac.ir/article-1-1143-en.pdf |
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