The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures
The integration of genetic and environmental factors that regulate the gene expression patterns associated with exercise adaptation is mediated by epigenetic mechanisms. The organisation of the human genome within three-dimensional space, known as chromosome conformation, has recently been shown as...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/11/8/905 |
| _version_ | 1797559653577523200 |
|---|---|
| author | Elliott C. R. Hall Christopher Murgatroyd Georgina K. Stebbings Brian Cunniffe Lee Harle Matthew Salter Aroul Ramadass Jurjen W. Westra Ewan Hunter Alexandre Akoulitchev Alun G. Williams |
| author_facet | Elliott C. R. Hall Christopher Murgatroyd Georgina K. Stebbings Brian Cunniffe Lee Harle Matthew Salter Aroul Ramadass Jurjen W. Westra Ewan Hunter Alexandre Akoulitchev Alun G. Williams |
| author_sort | Elliott C. R. Hall |
| collection | DOAJ |
| description | The integration of genetic and environmental factors that regulate the gene expression patterns associated with exercise adaptation is mediated by epigenetic mechanisms. The organisation of the human genome within three-dimensional space, known as chromosome conformation, has recently been shown as a dynamic epigenetic regulator of gene expression, facilitating the interaction of distal genomic regions due to tight and regulated packaging of chromosomes in the cell nucleus. Technological advances in the study of chromosome conformation mean a new class of biomarker—the chromosome conformation signature (CCS)—can identify chromosomal interactions across several genomic loci as a collective marker of an epigenomic state. Investigative use of CCSs in biological and medical research shows promise in identifying the likelihood that a disease state is present or absent, as well as an ability to prospectively stratify individuals according to their likely response to medical intervention. The association of CCSs with gene expression patterns suggests that there are likely to be CCSs that respond, or regulate the response, to exercise and related stimuli. The present review provides a contextual background to CCS research and a theoretical framework discussing the potential uses of this novel epigenomic biomarker within sport and exercise science and medicine. |
| first_indexed | 2024-03-10T17:49:23Z |
| format | Article |
| id | doaj.art-ec210bb222f344cfa94680cefa6fd263 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T17:49:23Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ec210bb222f344cfa94680cefa6fd2632023-11-20T09:26:37ZengMDPI AGGenes2073-44252020-08-0111890510.3390/genes11080905The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation SignaturesElliott C. R. Hall0Christopher Murgatroyd1Georgina K. Stebbings2Brian Cunniffe3Lee Harle4Matthew Salter5Aroul Ramadass6Jurjen W. Westra7Ewan Hunter8Alexandre Akoulitchev9Alun G. Williams10Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M1 5GD, UKDepartment of Life Sciences, Manchester Metropolitan University, Manchester M1 5GD, UKDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M1 5GD, UKEnglish Institute of Sport, Nottingham NG12 2LU, UKHolos Life Sciences, Oxford OX1 3HA, UKOxford BioDynamics, Oxford OX4 2JZ, UKOxford BioDynamics, Oxford OX4 2JZ, UKOxford BioDynamics, Oxford OX4 2JZ, UKOxford BioDynamics, Oxford OX4 2JZ, UKOxford BioDynamics, Oxford OX4 2JZ, UKDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M1 5GD, UKThe integration of genetic and environmental factors that regulate the gene expression patterns associated with exercise adaptation is mediated by epigenetic mechanisms. The organisation of the human genome within three-dimensional space, known as chromosome conformation, has recently been shown as a dynamic epigenetic regulator of gene expression, facilitating the interaction of distal genomic regions due to tight and regulated packaging of chromosomes in the cell nucleus. Technological advances in the study of chromosome conformation mean a new class of biomarker—the chromosome conformation signature (CCS)—can identify chromosomal interactions across several genomic loci as a collective marker of an epigenomic state. Investigative use of CCSs in biological and medical research shows promise in identifying the likelihood that a disease state is present or absent, as well as an ability to prospectively stratify individuals according to their likely response to medical intervention. The association of CCSs with gene expression patterns suggests that there are likely to be CCSs that respond, or regulate the response, to exercise and related stimuli. The present review provides a contextual background to CCS research and a theoretical framework discussing the potential uses of this novel epigenomic biomarker within sport and exercise science and medicine.https://www.mdpi.com/2073-4425/11/8/905geneticsepigeneticsexerciseexercise trainingchromatinsports medicine |
| spellingShingle | Elliott C. R. Hall Christopher Murgatroyd Georgina K. Stebbings Brian Cunniffe Lee Harle Matthew Salter Aroul Ramadass Jurjen W. Westra Ewan Hunter Alexandre Akoulitchev Alun G. Williams The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures Genes genetics epigenetics exercise exercise training chromatin sports medicine |
| title | The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures |
| title_full | The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures |
| title_fullStr | The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures |
| title_full_unstemmed | The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures |
| title_short | The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures |
| title_sort | prospective study of epigenetic regulatory profiles in sport and exercise monitored through chromosome conformation signatures |
| topic | genetics epigenetics exercise exercise training chromatin sports medicine |
| url | https://www.mdpi.com/2073-4425/11/8/905 |
| work_keys_str_mv | AT elliottcrhall theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT christophermurgatroyd theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT georginakstebbings theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT briancunniffe theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT leeharle theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT matthewsalter theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT aroulramadass theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT jurjenwwestra theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT ewanhunter theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT alexandreakoulitchev theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT alungwilliams theprospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT elliottcrhall prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT christophermurgatroyd prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT georginakstebbings prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT briancunniffe prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT leeharle prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT matthewsalter prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT aroulramadass prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT jurjenwwestra prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT ewanhunter prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT alexandreakoulitchev prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures AT alungwilliams prospectivestudyofepigeneticregulatoryprofilesinsportandexercisemonitoredthroughchromosomeconformationsignatures |