Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange
Abstract Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but new onset of ANCA-associated vasculitis after transplantation is highl...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1086-z |
| _version_ | 1818279204374970368 |
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| author | Michael S. Sagmeister Max Weiss Peter Eichhorn Antje Habicht Rupert Habersetzer Michael Fischereder Ulf Schönermarck |
| author_facet | Michael S. Sagmeister Max Weiss Peter Eichhorn Antje Habicht Rupert Habersetzer Michael Fischereder Ulf Schönermarck |
| author_sort | Michael S. Sagmeister |
| collection | DOAJ |
| description | Abstract Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but new onset of ANCA-associated vasculitis after transplantation is highly unusual. The use of rituximab or plasmapheresis for de novo disease after transplantation has not previously been reported. Case presentation Routine post-transplant follow-up for a 66-year old asymptomatic woman revealed a rise in creatinine from 1.8 to 2.6 mg/dl and increased proteinuria. She had received a cadaveric kidney transplant 20 months previously for end-stage autosomal dominant polycystic kidney disease. Renal allograft biopsy unexpectedly demonstrated pauci-immune glomerulonephritis with extracapillary proliferation and interstitial inflammation. Concurrent serum tested strongly positive for ANCA specific to proteinase 3 (PR3), but stored pre- and post-transplantation serum samples tested negative. These findings established a diagnosis of de novo ANCA-associated vasculitis in the renal allograft. We started treatment with high-dose corticosteroid and rituximab. Despite this, serum creatinine continued to rise and glomerulonephritis remained active in a repeat biopsy. Escalation of the treatment with seven sessions of plasmapheresis led to a temporary improvement in creatinine. No further features of vasculitis emerged and PR3-ANCA titres declined. However, multiple infections complicated the recovery period and were associated with progressive loss of renal transplant function. Four months after the index presentation, transplant function became insufficient and dialysis was restarted. Conclusions De novo ANCA-associated vasculitis after renal transplantation is exceptionally rare. It poses a significant risk to graft survival even in the context of intensified immunosuppression. Management relies on clinical evidence from populations with native renal function, yet post-transplant patients may be at increased risk of treatment-related adverse events. Precautions against these risks are crucial in the delivery of care. |
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| format | Article |
| id | doaj.art-ec210cad73214437aaf70ae50596aa99 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-12T23:29:37Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-ec210cad73214437aaf70ae50596aa992022-12-22T00:07:51ZengBMCBMC Nephrology1471-23692018-10-011911610.1186/s12882-018-1086-zCase report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchangeMichael S. Sagmeister0Max Weiss1Peter Eichhorn2Antje Habicht3Rupert Habersetzer4Michael Fischereder5Ulf Schönermarck6Nephrology Division, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München - Campus GroßhadernInstitute of Pathology, Ludwig-Maximilians-UniversitätInstitute of Laboratory Medicine, Ludwig-Maximilians-UniversitätCentre for Transplantation, Klinikum der Universität München - Campus GroßhadernKfH-Gesundheitszentrum Emmering / DachauNephrology Division, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München - Campus GroßhadernNephrology Division, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München - Campus GroßhadernAbstract Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but new onset of ANCA-associated vasculitis after transplantation is highly unusual. The use of rituximab or plasmapheresis for de novo disease after transplantation has not previously been reported. Case presentation Routine post-transplant follow-up for a 66-year old asymptomatic woman revealed a rise in creatinine from 1.8 to 2.6 mg/dl and increased proteinuria. She had received a cadaveric kidney transplant 20 months previously for end-stage autosomal dominant polycystic kidney disease. Renal allograft biopsy unexpectedly demonstrated pauci-immune glomerulonephritis with extracapillary proliferation and interstitial inflammation. Concurrent serum tested strongly positive for ANCA specific to proteinase 3 (PR3), but stored pre- and post-transplantation serum samples tested negative. These findings established a diagnosis of de novo ANCA-associated vasculitis in the renal allograft. We started treatment with high-dose corticosteroid and rituximab. Despite this, serum creatinine continued to rise and glomerulonephritis remained active in a repeat biopsy. Escalation of the treatment with seven sessions of plasmapheresis led to a temporary improvement in creatinine. No further features of vasculitis emerged and PR3-ANCA titres declined. However, multiple infections complicated the recovery period and were associated with progressive loss of renal transplant function. Four months after the index presentation, transplant function became insufficient and dialysis was restarted. Conclusions De novo ANCA-associated vasculitis after renal transplantation is exceptionally rare. It poses a significant risk to graft survival even in the context of intensified immunosuppression. Management relies on clinical evidence from populations with native renal function, yet post-transplant patients may be at increased risk of treatment-related adverse events. Precautions against these risks are crucial in the delivery of care.http://link.springer.com/article/10.1186/s12882-018-1086-zANCAVasculitisKidney transplantationde novoRituximabCase report |
| spellingShingle | Michael S. Sagmeister Max Weiss Peter Eichhorn Antje Habicht Rupert Habersetzer Michael Fischereder Ulf Schönermarck Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange BMC Nephrology ANCA Vasculitis Kidney transplantation de novo Rituximab Case report |
| title | Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| title_full | Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| title_fullStr | Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| title_full_unstemmed | Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| title_short | Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| title_sort | case report de novo anca associated vasculitis after kidney transplantation treated with rituximab and plasma exchange |
| topic | ANCA Vasculitis Kidney transplantation de novo Rituximab Case report |
| url | http://link.springer.com/article/10.1186/s12882-018-1086-z |
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