P2X and P2Y receptor signaling in red blood cells
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00060/full |
| _version_ | 1811214562511290368 |
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| author | Ronald eSluyter Ronald eSluyter Ronald eSluyter |
| author_facet | Ronald eSluyter Ronald eSluyter Ronald eSluyter |
| author_sort | Ronald eSluyter |
| collection | DOAJ |
| description | Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology. |
| first_indexed | 2024-04-12T06:06:46Z |
| format | Article |
| id | doaj.art-ec21c51bd62f44c2b396f8025048537e |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-12T06:06:46Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-ec21c51bd62f44c2b396f8025048537e2022-12-22T03:44:52ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2015-10-01210.3389/fmolb.2015.00060167625P2X and P2Y receptor signaling in red blood cellsRonald eSluyter0Ronald eSluyter1Ronald eSluyter2University of WollongongUniversity of WollongongIllawarra Health and Medical Research InstitutePurinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology.http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00060/fullAdenosine TriphosphateerythrocyteP2X7 receptorred blood cellpurinergic receptorP2X1 receptor |
| spellingShingle | Ronald eSluyter Ronald eSluyter Ronald eSluyter P2X and P2Y receptor signaling in red blood cells Frontiers in Molecular Biosciences Adenosine Triphosphate erythrocyte P2X7 receptor red blood cell purinergic receptor P2X1 receptor |
| title | P2X and P2Y receptor signaling in red blood cells |
| title_full | P2X and P2Y receptor signaling in red blood cells |
| title_fullStr | P2X and P2Y receptor signaling in red blood cells |
| title_full_unstemmed | P2X and P2Y receptor signaling in red blood cells |
| title_short | P2X and P2Y receptor signaling in red blood cells |
| title_sort | p2x and p2y receptor signaling in red blood cells |
| topic | Adenosine Triphosphate erythrocyte P2X7 receptor red blood cell purinergic receptor P2X1 receptor |
| url | http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00060/full |
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