Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats
Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/7/602 |
| _version_ | 1797417116396158976 |
|---|---|
| author | Barbara Barath Adam Varga Adam Attila Matrai Krisztina Deak-Pocsai Norbert Nemeth Adam Deak |
| author_facet | Barbara Barath Adam Varga Adam Attila Matrai Krisztina Deak-Pocsai Norbert Nemeth Adam Deak |
| author_sort | Barbara Barath |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological and micro-rheological study on experimentally induced PCOS in rats.Wistar rats were divided into control (n = 9) and PCOS groups (n = 9), in which animals received single-dose estradiol valerate. Measurements were carried out before treatment and monthly for four months. Bodyweight, blood glucose concentration, hematological parameters, red blood cell (RBC) deformability, and aggregation were measured. A histological examination of the ovary was performed at the end of the experiment. The blood glucose level and the bodyweight were significantly elevated vs. base in the PCOS group. A significant decrease was seen in RBC count, hemoglobin, and hematocrit. The maximal elongation index showed a significant increase. PCOS also resulted in a significant increase in RBC aggregation index parameters. The histological and hormone examinations confirmed developed PCOS. The administration of estradiol valerate caused significant changes during the examined period in hematological and hemorheological parameters. Our results draw attention to the possible usefulness of micro-rheological investigations in further studies on PCOS. |
| first_indexed | 2024-03-09T06:14:10Z |
| format | Article |
| id | doaj.art-ec22407f9eb743d49378867ef5abd14d |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T06:14:10Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ec22407f9eb743d49378867ef5abd14d2023-12-03T11:55:54ZengMDPI AGMetabolites2218-19892022-06-0112760210.3390/metabo12070602Estradiol Valerate Affects Hematological and Hemorheological Parameters in RatsBarbara Barath0Adam Varga1Adam Attila Matrai2Krisztina Deak-Pocsai3Norbert Nemeth4Adam Deak5Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, HungaryPolycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological and micro-rheological study on experimentally induced PCOS in rats.Wistar rats were divided into control (n = 9) and PCOS groups (n = 9), in which animals received single-dose estradiol valerate. Measurements were carried out before treatment and monthly for four months. Bodyweight, blood glucose concentration, hematological parameters, red blood cell (RBC) deformability, and aggregation were measured. A histological examination of the ovary was performed at the end of the experiment. The blood glucose level and the bodyweight were significantly elevated vs. base in the PCOS group. A significant decrease was seen in RBC count, hemoglobin, and hematocrit. The maximal elongation index showed a significant increase. PCOS also resulted in a significant increase in RBC aggregation index parameters. The histological and hormone examinations confirmed developed PCOS. The administration of estradiol valerate caused significant changes during the examined period in hematological and hemorheological parameters. Our results draw attention to the possible usefulness of micro-rheological investigations in further studies on PCOS.https://www.mdpi.com/2218-1989/12/7/602polycystic ovary syndromeanimal modelhematologyhemorheologyred blood cell aggregationred blood cell deformability |
| spellingShingle | Barbara Barath Adam Varga Adam Attila Matrai Krisztina Deak-Pocsai Norbert Nemeth Adam Deak Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats Metabolites polycystic ovary syndrome animal model hematology hemorheology red blood cell aggregation red blood cell deformability |
| title | Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats |
| title_full | Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats |
| title_fullStr | Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats |
| title_full_unstemmed | Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats |
| title_short | Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats |
| title_sort | estradiol valerate affects hematological and hemorheological parameters in rats |
| topic | polycystic ovary syndrome animal model hematology hemorheology red blood cell aggregation red blood cell deformability |
| url | https://www.mdpi.com/2218-1989/12/7/602 |
| work_keys_str_mv | AT barbarabarath estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats AT adamvarga estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats AT adamattilamatrai estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats AT krisztinadeakpocsai estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats AT norbertnemeth estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats AT adamdeak estradiolvalerateaffectshematologicalandhemorheologicalparametersinrats |