Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study
Abstract Objective In this study, we used ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA) to assess changes in retinal thickness (RT) and choroidal parameters in individuals who had received a diagnosis of central serous chorioretinopathy (CSC). Methods The study...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03405-w |
| _version_ | 1797199577841926144 |
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| author | Bei Xiao Ming Yan Yan-Ping Song Ya Ye Zhen Huang |
| author_facet | Bei Xiao Ming Yan Yan-Ping Song Ya Ye Zhen Huang |
| author_sort | Bei Xiao |
| collection | DOAJ |
| description | Abstract Objective In this study, we used ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA) to assess changes in retinal thickness (RT) and choroidal parameters in individuals who had received a diagnosis of central serous chorioretinopathy (CSC). Methods The study encompassed the evaluation of 59 eyes from 47 patients with a diagnosis of CSC, alongside 33 fellow eyes and 31 eyes from healthy individuals (controls). The parameters assessed included RT, choroidal thickness (CT), choriocapillaris density, vascular density of the large choroidal vessel layer, three-dimensional choroidal vascularity index (3D-CVI), choroidal vessel volume per unit area (mCVV/a), and choroidal stroma volume per unit area (mCSV/a). Results Metrics including mCVV/a, mCSV/a, 3D-CVI, CT, and RT exhibited significantly elevated values in the eyes affected by CSC compared to those of the control group across nine subfields. Moreover, a substantial number of the subfields in both CSC-affected and fellow eyes exhibited increased values for mCVV/a, mCSV/a, 3D-CVI, CT, and RT when compared with the control group. Additionally, acute and chronic CSC subfields demonstrated significantly elevated values for mCVV/a, mCSV/a, 3D-CVI, CT, and RT in comparison to healthy control eyes. Notably, specific subfields associated with complex and atypical forms of CSC revealed higher metrics compared to those of the control group. Conclusion In conclusion, the UWF SS-OCTA proved to be a valuable tool for exploring the anatomical etiology and clinical classification and diagnosis of CSC. |
| first_indexed | 2024-04-24T07:17:58Z |
| format | Article |
| id | doaj.art-ec22aa4112474e4490f4871771a82135 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-24T07:17:58Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-ec22aa4112474e4490f4871771a821352024-04-21T11:12:34ZengBMCBMC Ophthalmology1471-24152024-04-0124111210.1186/s12886-024-03405-wQuantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional studyBei Xiao0Ming Yan1Yan-Ping Song2Ya Ye3Zhen Huang4The First School of Clinical Medicine, Southern Medical UniversityThe Department of Ophthalmology, General Hospital of Central Theater CommandThe First School of Clinical Medicine, Southern Medical UniversityThe First School of Clinical Medicine, Southern Medical UniversityThe Department of Ophthalmology, General Hospital of Central Theater CommandAbstract Objective In this study, we used ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA) to assess changes in retinal thickness (RT) and choroidal parameters in individuals who had received a diagnosis of central serous chorioretinopathy (CSC). Methods The study encompassed the evaluation of 59 eyes from 47 patients with a diagnosis of CSC, alongside 33 fellow eyes and 31 eyes from healthy individuals (controls). The parameters assessed included RT, choroidal thickness (CT), choriocapillaris density, vascular density of the large choroidal vessel layer, three-dimensional choroidal vascularity index (3D-CVI), choroidal vessel volume per unit area (mCVV/a), and choroidal stroma volume per unit area (mCSV/a). Results Metrics including mCVV/a, mCSV/a, 3D-CVI, CT, and RT exhibited significantly elevated values in the eyes affected by CSC compared to those of the control group across nine subfields. Moreover, a substantial number of the subfields in both CSC-affected and fellow eyes exhibited increased values for mCVV/a, mCSV/a, 3D-CVI, CT, and RT when compared with the control group. Additionally, acute and chronic CSC subfields demonstrated significantly elevated values for mCVV/a, mCSV/a, 3D-CVI, CT, and RT in comparison to healthy control eyes. Notably, specific subfields associated with complex and atypical forms of CSC revealed higher metrics compared to those of the control group. Conclusion In conclusion, the UWF SS-OCTA proved to be a valuable tool for exploring the anatomical etiology and clinical classification and diagnosis of CSC.https://doi.org/10.1186/s12886-024-03405-wCentral serous chorioretinopathy (CSC)ChoroidSwept-source optical coherence tomography angiography (SS-OCTA)Three-dimensional choroidal vessel index |
| spellingShingle | Bei Xiao Ming Yan Yan-Ping Song Ya Ye Zhen Huang Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study BMC Ophthalmology Central serous chorioretinopathy (CSC) Choroid Swept-source optical coherence tomography angiography (SS-OCTA) Three-dimensional choroidal vessel index |
| title | Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study |
| title_full | Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study |
| title_fullStr | Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study |
| title_full_unstemmed | Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study |
| title_short | Quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography: a cross-sectional study |
| title_sort | quantitative assessment of choroidal parameters and retinal thickness in central serous chorioretinopathy using ultra widefield swept source optical coherence tomography a cross sectional study |
| topic | Central serous chorioretinopathy (CSC) Choroid Swept-source optical coherence tomography angiography (SS-OCTA) Three-dimensional choroidal vessel index |
| url | https://doi.org/10.1186/s12886-024-03405-w |
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