Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers
This study aimed (1) to assess serum trace elements concentrations and hematological parameters, (2) to evaluate the sex differences in the associations between serum trace elements levels and hematological parameters, and (3) to identify the associations between serum trace elements concentrations...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1615 |
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| author | Kyi Mar Wai Kaori Sawada Mika Kumagai Kazuyoshi Itai Itoyo Tokuda Koichi Murashita Shigeyuki Nakaji Kazushige Ihara |
| author_facet | Kyi Mar Wai Kaori Sawada Mika Kumagai Kazuyoshi Itai Itoyo Tokuda Koichi Murashita Shigeyuki Nakaji Kazushige Ihara |
| author_sort | Kyi Mar Wai |
| collection | DOAJ |
| description | This study aimed (1) to assess serum trace elements concentrations and hematological parameters, (2) to evaluate the sex differences in the associations between serum trace elements levels and hematological parameters, and (3) to identify the associations between serum trace elements concentrations and risk of anemia among Japanese community dwellers. This is a community-based cross-sectional study that utilized the data of the 2014 Iwaki Health Promotion Project. Participants were 1176 community dwellers (>18 years) residing in the Iwaki District, Aomori Prefecture, Japan. We assessed the data of serum trace elements concentrations of cadmium (Cd), cobalt (Co), copper (Cu), selenium (Se), zinc (Zn), and iron (Fe) as well as the hematological parameters of red blood cells (RBC) counts, hemoglobin, packed cells volume (PCV), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Serum concentrations of Zn (871.5 μg/L vs. 900.1 μg/L) and Fe (946.8 μg/L vs. 1096.1 μg/L) were significantly lower in females than in males, while serum concentrations of Co (0.4 μg/L vs. 0.3 μg/L) and Cu (1062.4 μg/L vs. 965.3 μg/L) were significantly higher in females. By multivariate linear regression, serum Se concentration was significantly, positively associated with PCV (β = 1.04; 95% confidence interval (CI): 0.17, 1.92; <i>p</i> = 0.016) among the study participants. Serum Zn also had positive associations with hemoglobin (β = 0.42; 95% CI: 0.07, 0.77; <i>p</i> = 0.020), PCV (β = 1.79; 95% CI: 0.78, 2.81; <i>p</i> < 0.001), and RBCs count (β = 15.56; 95% CI: 7.31, 31.69; <i>p</i> = 0.002). On the other hand, serum Co concentration was negatively associated with the hematological parameters, particularly in females. Moreover, serum Zn concentration had a decreased risk of anemia (lowest vs. highest quartiles: odds ratio (OR) = 0.42; 95% CI: 0.23, 0.76; <i>p</i> = 0.005) while higher Co concentrations had an increased risk of anemia (lowest vs. highest quartiles: OR = 1.95; 95% CI: 1.04, 3.67; <i>p</i> = 0.037). However, no significant association was found between serum Cu level and hematological parameters. There were substantial sex differences in serum trace elements, implying that trace elements metabolism differed between males and females. Zn can play a protective role in the development of anemia. Surprisingly, increased Co concentration increased the risk of anemia among our study population, which called for further studies to confirm and to consider for speciation analysis. |
| first_indexed | 2024-03-10T19:29:11Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-10T19:29:11Z |
| publishDate | 2020-05-01 |
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| series | Nutrients |
| spelling | doaj.art-ec22bca268a24e94bef233841b24f3bf2023-11-20T02:19:16ZengMDPI AGNutrients2072-66432020-05-01126161510.3390/nu12061615Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community DwellersKyi Mar Wai0Kaori Sawada1Mika Kumagai2Kazuyoshi Itai3Itoyo Tokuda4Koichi Murashita5Shigeyuki Nakaji6Kazushige Ihara7Department of Mibyo Science, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki 036-8562, JapanDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Active Life Promotion, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Nutritional Sciences, Morioka University, Iwate 020-0694, JapanDepartment of Oral Health Care, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanCenter of Innovation, Research Initiatives Organization, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Mibyo Science, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki 036-8562, JapanDepartment of Mibyo Science, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki 036-8562, JapanThis study aimed (1) to assess serum trace elements concentrations and hematological parameters, (2) to evaluate the sex differences in the associations between serum trace elements levels and hematological parameters, and (3) to identify the associations between serum trace elements concentrations and risk of anemia among Japanese community dwellers. This is a community-based cross-sectional study that utilized the data of the 2014 Iwaki Health Promotion Project. Participants were 1176 community dwellers (>18 years) residing in the Iwaki District, Aomori Prefecture, Japan. We assessed the data of serum trace elements concentrations of cadmium (Cd), cobalt (Co), copper (Cu), selenium (Se), zinc (Zn), and iron (Fe) as well as the hematological parameters of red blood cells (RBC) counts, hemoglobin, packed cells volume (PCV), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Serum concentrations of Zn (871.5 μg/L vs. 900.1 μg/L) and Fe (946.8 μg/L vs. 1096.1 μg/L) were significantly lower in females than in males, while serum concentrations of Co (0.4 μg/L vs. 0.3 μg/L) and Cu (1062.4 μg/L vs. 965.3 μg/L) were significantly higher in females. By multivariate linear regression, serum Se concentration was significantly, positively associated with PCV (β = 1.04; 95% confidence interval (CI): 0.17, 1.92; <i>p</i> = 0.016) among the study participants. Serum Zn also had positive associations with hemoglobin (β = 0.42; 95% CI: 0.07, 0.77; <i>p</i> = 0.020), PCV (β = 1.79; 95% CI: 0.78, 2.81; <i>p</i> < 0.001), and RBCs count (β = 15.56; 95% CI: 7.31, 31.69; <i>p</i> = 0.002). On the other hand, serum Co concentration was negatively associated with the hematological parameters, particularly in females. Moreover, serum Zn concentration had a decreased risk of anemia (lowest vs. highest quartiles: odds ratio (OR) = 0.42; 95% CI: 0.23, 0.76; <i>p</i> = 0.005) while higher Co concentrations had an increased risk of anemia (lowest vs. highest quartiles: OR = 1.95; 95% CI: 1.04, 3.67; <i>p</i> = 0.037). However, no significant association was found between serum Cu level and hematological parameters. There were substantial sex differences in serum trace elements, implying that trace elements metabolism differed between males and females. Zn can play a protective role in the development of anemia. Surprisingly, increased Co concentration increased the risk of anemia among our study population, which called for further studies to confirm and to consider for speciation analysis.https://www.mdpi.com/2072-6643/12/6/1615trace elementsmetalshematological parametersanemiaIwaki |
| spellingShingle | Kyi Mar Wai Kaori Sawada Mika Kumagai Kazuyoshi Itai Itoyo Tokuda Koichi Murashita Shigeyuki Nakaji Kazushige Ihara Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers Nutrients trace elements metals hematological parameters anemia Iwaki |
| title | Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers |
| title_full | Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers |
| title_fullStr | Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers |
| title_full_unstemmed | Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers |
| title_short | Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers |
| title_sort | relationship between selected trace elements and hematological parameters among japanese community dwellers |
| topic | trace elements metals hematological parameters anemia Iwaki |
| url | https://www.mdpi.com/2072-6643/12/6/1615 |
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