A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression
Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as th...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/2/246 |
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| author | Yesim Yeni Zeynep Cakir Ahmet Hacimuftuoglu Ali Taghizadehghalehjoughi Ufuk Okkay Sidika Genc Serkan Yildirim Yavuz Selim Saglam Daniela Calina Aristidis Tsatsakis Anca Oana Docea |
| author_facet | Yesim Yeni Zeynep Cakir Ahmet Hacimuftuoglu Ali Taghizadehghalehjoughi Ufuk Okkay Sidika Genc Serkan Yildirim Yavuz Selim Saglam Daniela Calina Aristidis Tsatsakis Anca Oana Docea |
| author_sort | Yesim Yeni |
| collection | DOAJ |
| description | Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as the main immune system histamine receptor with a pro-inflammatory role. To understand the role of this receptor, the drug JNJ7777120 was used to reveal the chronic depression-glutamate relationship. We have important findings showing that the H4 antagonist increases the glutamate transporters’ instantaneous activity. In our experiment, it has been shown that blocking the H4 receptor leads to increased neuron cell viability and improvement in behavioral ability due to glutamate. Therefore, JNJ can be used to prevent neurotoxicity, inhibit membrane phospholipase activation and free radical formation, and minimize membrane disruption. In line with our findings, results have been obtained that indicate that JNJ will contribute to the effective prevention and treatment of depression. |
| first_indexed | 2024-03-09T21:37:46Z |
| format | Article |
| id | doaj.art-ec234e7f680d4b8ba70dd6a75b499b49 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T21:37:46Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-ec234e7f680d4b8ba70dd6a75b499b492023-11-23T20:40:27ZengMDPI AGJournal of Personalized Medicine2075-44262022-02-0112224610.3390/jpm12020246A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic DepressionYesim Yeni0Zeynep Cakir1Ahmet Hacimuftuoglu2Ali Taghizadehghalehjoughi3Ufuk Okkay4Sidika Genc5Serkan Yildirim6Yavuz Selim Saglam7Daniela Calina8Aristidis Tsatsakis9Anca Oana Docea10Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, TurkeyDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, GreeceDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaGlutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as the main immune system histamine receptor with a pro-inflammatory role. To understand the role of this receptor, the drug JNJ7777120 was used to reveal the chronic depression-glutamate relationship. We have important findings showing that the H4 antagonist increases the glutamate transporters’ instantaneous activity. In our experiment, it has been shown that blocking the H4 receptor leads to increased neuron cell viability and improvement in behavioral ability due to glutamate. Therefore, JNJ can be used to prevent neurotoxicity, inhibit membrane phospholipase activation and free radical formation, and minimize membrane disruption. In line with our findings, results have been obtained that indicate that JNJ will contribute to the effective prevention and treatment of depression.https://www.mdpi.com/2075-4426/12/2/246depressionglutamateH4hippocampusJNJ7777120 |
| spellingShingle | Yesim Yeni Zeynep Cakir Ahmet Hacimuftuoglu Ali Taghizadehghalehjoughi Ufuk Okkay Sidika Genc Serkan Yildirim Yavuz Selim Saglam Daniela Calina Aristidis Tsatsakis Anca Oana Docea A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression Journal of Personalized Medicine depression glutamate H4 hippocampus JNJ7777120 |
| title | A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression |
| title_full | A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression |
| title_fullStr | A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression |
| title_full_unstemmed | A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression |
| title_short | A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression |
| title_sort | selective histamine h4 receptor antagonist jnj7777120 role on glutamate transporter activity in chronic depression |
| topic | depression glutamate H4 hippocampus JNJ7777120 |
| url | https://www.mdpi.com/2075-4426/12/2/246 |
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