A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as th...

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Bibliographic Details
Main Authors: Yesim Yeni, Zeynep Cakir, Ahmet Hacimuftuoglu, Ali Taghizadehghalehjoughi, Ufuk Okkay, Sidika Genc, Serkan Yildirim, Yavuz Selim Saglam, Daniela Calina, Aristidis Tsatsakis, Anca Oana Docea
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Journal of Personalized Medicine
Subjects:
depression
glutamate
H4
hippocampus
JNJ7777120
Online Access:https://www.mdpi.com/2075-4426/12/2/246

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