Optical-Quality Assessment of a Miniaturized Intraocular Telescope
Age-related macular degeneration (AMD) causes severe vision impairments, including blindness. An option to improve vision in AMD patients is through intraocular lenses and optics. Among others, implantable miniaturized telescopes, which direct light to healthy lateral regions of the retina, can be h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/10/3375 |
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| author | Irene Nepita Raffaele Raimondi Simonluca Piazza Alberto Diaspro Faustino Vidal-Aroca Salvatore Surdo Mario R. Romano |
| author_facet | Irene Nepita Raffaele Raimondi Simonluca Piazza Alberto Diaspro Faustino Vidal-Aroca Salvatore Surdo Mario R. Romano |
| author_sort | Irene Nepita |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) causes severe vision impairments, including blindness. An option to improve vision in AMD patients is through intraocular lenses and optics. Among others, implantable miniaturized telescopes, which direct light to healthy lateral regions of the retina, can be highly effective in improving vision in AMD patients. Yet, the quality of the restored vision might be sensitive to the optical transmission and aberrations of the telescope. To shed light on these points, we studied the in vitro optical performance of an implantable miniaturized telescope, namely, the SING IMT™ (Samsara Vision Ltd., Far Hills, NJ, USA) designed to improve vision in patients affected by late-stage AMD. Specifically, we measured the optical transmission in the spectral range 350–750 nm of the implantable telescope with a fiber-optic spectrometer. Wavefront aberrations were studied by measuring the wavefront of a laser beam after passing through the telescope and expanding the measured wavefront into a Zernike polynomial basis. Wavefront concavity indicated that the SING IMT™ behaves as a diverging lens with a focal length of −111 mm. The device exhibited even optical transmission in the whole visible spectrum and effective curvature suitable for retinal images magnification with negligible geometrical aberrations. Optical spectrometry and in vitro wavefront analysis provide evidence supporting the feasibility of miniaturized telescopes as high-quality optical elements and a favorable option for AMD visual impairment treatments. |
| first_indexed | 2024-03-11T03:38:01Z |
| format | Article |
| id | doaj.art-ec24cf73f88d44da9a6a5a11fc3c4f5a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:38:01Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ec24cf73f88d44da9a6a5a11fc3c4f5a2023-11-18T01:51:52ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011210337510.3390/jcm12103375Optical-Quality Assessment of a Miniaturized Intraocular TelescopeIrene Nepita0Raffaele Raimondi1Simonluca Piazza2Alberto Diaspro3Faustino Vidal-Aroca4Salvatore Surdo5Mario R. Romano6Nanoscopy, Istituto Italiano di Tecnologia, Via E. Melen 83, 16152 Genova, ItalyDepartment of Biomedical Sciences, Humanitas University, 20090 Milano, ItalyNanoscopy, Istituto Italiano di Tecnologia, Via E. Melen 83, 16152 Genova, ItalyNanoscopy, Istituto Italiano di Tecnologia, Via E. Melen 83, 16152 Genova, ItalyDepartment of Scientific Affairs, Medevise Consulting, 67000 Strasbourg, FranceGenoa Instruments s.r.l., Via E. Melen 83, 16152 Genoa, ItalyDepartment of Biomedical Sciences, Humanitas University, 20090 Milano, ItalyAge-related macular degeneration (AMD) causes severe vision impairments, including blindness. An option to improve vision in AMD patients is through intraocular lenses and optics. Among others, implantable miniaturized telescopes, which direct light to healthy lateral regions of the retina, can be highly effective in improving vision in AMD patients. Yet, the quality of the restored vision might be sensitive to the optical transmission and aberrations of the telescope. To shed light on these points, we studied the in vitro optical performance of an implantable miniaturized telescope, namely, the SING IMT™ (Samsara Vision Ltd., Far Hills, NJ, USA) designed to improve vision in patients affected by late-stage AMD. Specifically, we measured the optical transmission in the spectral range 350–750 nm of the implantable telescope with a fiber-optic spectrometer. Wavefront aberrations were studied by measuring the wavefront of a laser beam after passing through the telescope and expanding the measured wavefront into a Zernike polynomial basis. Wavefront concavity indicated that the SING IMT™ behaves as a diverging lens with a focal length of −111 mm. The device exhibited even optical transmission in the whole visible spectrum and effective curvature suitable for retinal images magnification with negligible geometrical aberrations. Optical spectrometry and in vitro wavefront analysis provide evidence supporting the feasibility of miniaturized telescopes as high-quality optical elements and a favorable option for AMD visual impairment treatments.https://www.mdpi.com/2077-0383/12/10/3375end-stage age-related macular degenerationvisual impairmentvisual prosthesisimplantable ophthalmic deviceintraocular lensoptical performance |
| spellingShingle | Irene Nepita Raffaele Raimondi Simonluca Piazza Alberto Diaspro Faustino Vidal-Aroca Salvatore Surdo Mario R. Romano Optical-Quality Assessment of a Miniaturized Intraocular Telescope Journal of Clinical Medicine end-stage age-related macular degeneration visual impairment visual prosthesis implantable ophthalmic device intraocular lens optical performance |
| title | Optical-Quality Assessment of a Miniaturized Intraocular Telescope |
| title_full | Optical-Quality Assessment of a Miniaturized Intraocular Telescope |
| title_fullStr | Optical-Quality Assessment of a Miniaturized Intraocular Telescope |
| title_full_unstemmed | Optical-Quality Assessment of a Miniaturized Intraocular Telescope |
| title_short | Optical-Quality Assessment of a Miniaturized Intraocular Telescope |
| title_sort | optical quality assessment of a miniaturized intraocular telescope |
| topic | end-stage age-related macular degeneration visual impairment visual prosthesis implantable ophthalmic device intraocular lens optical performance |
| url | https://www.mdpi.com/2077-0383/12/10/3375 |
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