Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome
Several studies found that most patients with Parkinson's disorder (PD) appear to have psychiatric symptoms such as depression, anxiety, hallucination, delusion, and cognitive dysfunction. Therefore, recognizing these psychiatrically symptoms of PD patients is crucial for both symptomatic thera...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1232805/full |
| _version_ | 1828717879445422080 |
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| author | Md Asif Nashiry Shauli Sarmin Sumi Salem A. Alyami Mohammad Ali Moni Mohammad Ali Moni |
| author_facet | Md Asif Nashiry Shauli Sarmin Sumi Salem A. Alyami Mohammad Ali Moni Mohammad Ali Moni |
| author_sort | Md Asif Nashiry |
| collection | DOAJ |
| description | Several studies found that most patients with Parkinson's disorder (PD) appear to have psychiatric symptoms such as depression, anxiety, hallucination, delusion, and cognitive dysfunction. Therefore, recognizing these psychiatrically symptoms of PD patients is crucial for both symptomatic therapy and better knowledge of the pathophysiology of PD. In order to address this issue, we created a bioinformatics framework to determine the effects of PD mRNA expression on understanding its relationship with psychiatric symptoms in PD patients. We have discovered a significant overlap between the sets of differentially expressed genes from PD exposed tissue and psychiatric disordered tissues using RNA-seq datasets. We have chosen Bipolar disorder and Schizophrenia as psychiatric disorders in our study. A number of significant correlations between PD and the occurrence of psychiatric diseases were also found by gene set enrichment analysis, investigations of the protein-protein interaction network, gene regulatory network, and protein-chemical agent interaction network. We anticipate that the results of this pathogenetic study will provide crucial information for understanding the intricate relationship between PD and psychiatric diseases. |
| first_indexed | 2024-03-12T14:34:48Z |
| format | Article |
| id | doaj.art-ec25b55dadbf4970a9cb97ef792eac16 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-12T14:34:48Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-ec25b55dadbf4970a9cb97ef792eac162023-08-17T12:12:00ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-08-011610.3389/fnmol.2023.12328051232805Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptomeMd Asif Nashiry0Shauli Sarmin Sumi1Salem A. Alyami2Mohammad Ali Moni3Mohammad Ali Moni4Data Analytics, Northern Alberta Institute of Technology, Edmonton, AB, CanadaComputer Science and Engineering, Jashore University of Science and Technology, Jashore, BangladeshMathematics and Statistics, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaArtificial Intelligence and Data Science, Faculty of Health and Behavioural Sciences, School of Health and Rehabilitation Sciences, The University of Queensland, Saint Lucia, QLD, AustraliaArtificial Intelligence and Cyber Futures Institute, Charles Stuart University, Bathurst, NSW, AustraliaSeveral studies found that most patients with Parkinson's disorder (PD) appear to have psychiatric symptoms such as depression, anxiety, hallucination, delusion, and cognitive dysfunction. Therefore, recognizing these psychiatrically symptoms of PD patients is crucial for both symptomatic therapy and better knowledge of the pathophysiology of PD. In order to address this issue, we created a bioinformatics framework to determine the effects of PD mRNA expression on understanding its relationship with psychiatric symptoms in PD patients. We have discovered a significant overlap between the sets of differentially expressed genes from PD exposed tissue and psychiatric disordered tissues using RNA-seq datasets. We have chosen Bipolar disorder and Schizophrenia as psychiatric disorders in our study. A number of significant correlations between PD and the occurrence of psychiatric diseases were also found by gene set enrichment analysis, investigations of the protein-protein interaction network, gene regulatory network, and protein-chemical agent interaction network. We anticipate that the results of this pathogenetic study will provide crucial information for understanding the intricate relationship between PD and psychiatric diseases.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1232805/fullParkinson's diseasepsychiatric disorderbipolar disorderschizophreniadifferentially expressed genes |
| spellingShingle | Md Asif Nashiry Shauli Sarmin Sumi Salem A. Alyami Mohammad Ali Moni Mohammad Ali Moni Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome Frontiers in Molecular Neuroscience Parkinson's disease psychiatric disorder bipolar disorder schizophrenia differentially expressed genes |
| title | Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome |
| title_full | Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome |
| title_fullStr | Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome |
| title_full_unstemmed | Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome |
| title_short | Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome |
| title_sort | systems biology approach discovers comorbidity interaction of parkinson s disease with psychiatric disorders utilizing brain transcriptome |
| topic | Parkinson's disease psychiatric disorder bipolar disorder schizophrenia differentially expressed genes |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1232805/full |
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