Longitudinal study on nerve ultrasound and corneal confocal microscopy in NF155 paranodopathy

Abstract We report the case of a 27‐year‐old patient with subacute anti‐neurofascin‐155 neuropathy with bifacial palsy, who showed excellent response to rituximab. We provide longitudinal data of established clinical scores, nerve conduction studies, antibody titers, and novel imaging methods (nerve...

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Bibliographic Details
Main Authors: Diamantis Athanasopoulos, Jeremias Motte, Anna Lena Fisse, Thomas Grueter, Nadine Trampe, Dietrich Sturm, Martin Tegenthoff, Melissa Sgodzai, Rafael Klimas, Luis Querol, Ralf Gold, Kalliopi Pitarokoili
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51061
Description
Summary:Abstract We report the case of a 27‐year‐old patient with subacute anti‐neurofascin‐155 neuropathy with bifacial palsy, who showed excellent response to rituximab. We provide longitudinal data of established clinical scores, nerve conduction studies, antibody titers, and novel imaging methods (nerve ultrasonography and corneal confocal microscopy). Clinical and electrophysiological improvement followed the reduction of serum antibody titer and correlated with a reduction of corneal inflammatory cellular infiltrates whereas the increase in the cross‐sectional area of the peripheral nerves remained 12 months after first manifestation. Our findings suggest that novel techniques provide useful follow‐up parameters in paranodopathies.
ISSN:2328-9503