Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
Background Hepatokines are a variety of proteins secreted by the liver, a key organ involved in systemic metabolism and endocrine, directly affect the liver glycolipid metabolism, and play an important role in the development of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM). Ec...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-03-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220660.pdf |
| _version_ | 1797216869934956544 |
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| author | QIAN Fangfang, CAI Zhensheng, GU Tian, LI Haoxiang, ZHAO Li, YANG Ling, DENG Xia, YUAN Guoyue |
| author_facet | QIAN Fangfang, CAI Zhensheng, GU Tian, LI Haoxiang, ZHAO Li, YANG Ling, DENG Xia, YUAN Guoyue |
| author_sort | QIAN Fangfang, CAI Zhensheng, GU Tian, LI Haoxiang, ZHAO Li, YANG Ling, DENG Xia, YUAN Guoyue |
| collection | DOAJ |
| description | Background Hepatokines are a variety of proteins secreted by the liver, a key organ involved in systemic metabolism and endocrine, directly affect the liver glycolipid metabolism, and play an important role in the development of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM). Ectodysplasin A (EDA) is a newly discovered hepatokine, which is considered to be strongly related to diabetes, obesity and insulin resistance. Objective To assess the relationship between serum EDA level and the risk of NAFLD in patients with T2DM. Methods One hundred and thirty T2DM patients, including 74 males (56.92%) and 56 females (43.08%), with a mean age of (55.6±12.4) years, were recruited from Department of Endocrinology, Affiliated Hospital of Jiangsu University between November 2017 and November 2020. Baseline data, results of glucose tolerance test, insulin response test, C-peptide response to glucagon test, and color Doppler ultrasound of the abdomen were collected. Baseline data were compared between patients with ultrasound-detected NAFLD (n=80) and those without (n=50). Pearson correlation analysis was used to evaluate the correlation between serum EDA and the other clinical and biochemical indices. Multiple linear regression analysis was used to explore the influencing factors of EDA level. Multivariate Logistic regression analysis was used to explore the effect of EDA level on the risk of NAFLD. Results Compared with non-NAFLD group, NAFLD group had much younger mean age, shorter mean duration of T2DM, but significantly higher mean levels of BMI, fasting insulin (FIns), 2-hour postprandial insulin responses (2 hIns), fasting C-peptide (FCP), 2-hour postprandial C-peptide (2 hCP), homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood uric acid (SUA), urea nitrogen (BUN), and EDA level (P<0.05). Pearson correlation analysis showed that the serum EDA level was positively correlated with age, FIns, 2 hIns, HOMA-IR, and AST (r=0.222, 0.186, 0.233, 0.204, 0.189, P<0.05). Multiple linear regression analysis showed that age〔β=1.957, 95%CI (0.412, 3.502), P=0.013〕, WHR〔β=-328.845, 95%CI (-638.903, -18.788), P=0.038〕, 2 hIns〔β=0.523, 95%CI (0.036, 1.011), P=0.036〕 and AST〔β=2.148, 95%CI (0.520, 3.776), P=0.010〕were independently associated with EDA (P<0.05). Multivariate Logistic regression analysis demonstrated that EDA was still associated with NAFLD after adjusting for multiple confounding factors〔OR=1.006, 95%CI (1.002, 1.010), P=0.007〕. Conclusion In T2DM patients with NAFLD, the level of serum EDA was significantly increased, and potentially associated with elevated risk of NAFLD, which suggests that serum EDA level may play a role in the development of NAFLD in T2DM. Our study may provide a theoretical basis for early screening or treatment of NAFLD. |
| first_indexed | 2024-04-24T11:52:49Z |
| format | Article |
| id | doaj.art-ec261e6a1b544e0381171b3737d007c6 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:52:49Z |
| publishDate | 2023-03-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-ec261e6a1b544e0381171b3737d007c62024-04-09T07:20:20ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-03-01260891191610.12114/j.issn.1007-9572.2022.0660Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes MellitusQIAN Fangfang, CAI Zhensheng, GU Tian, LI Haoxiang, ZHAO Li, YANG Ling, DENG Xia, YUAN Guoyue0Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaBackground Hepatokines are a variety of proteins secreted by the liver, a key organ involved in systemic metabolism and endocrine, directly affect the liver glycolipid metabolism, and play an important role in the development of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM). Ectodysplasin A (EDA) is a newly discovered hepatokine, which is considered to be strongly related to diabetes, obesity and insulin resistance. Objective To assess the relationship between serum EDA level and the risk of NAFLD in patients with T2DM. Methods One hundred and thirty T2DM patients, including 74 males (56.92%) and 56 females (43.08%), with a mean age of (55.6±12.4) years, were recruited from Department of Endocrinology, Affiliated Hospital of Jiangsu University between November 2017 and November 2020. Baseline data, results of glucose tolerance test, insulin response test, C-peptide response to glucagon test, and color Doppler ultrasound of the abdomen were collected. Baseline data were compared between patients with ultrasound-detected NAFLD (n=80) and those without (n=50). Pearson correlation analysis was used to evaluate the correlation between serum EDA and the other clinical and biochemical indices. Multiple linear regression analysis was used to explore the influencing factors of EDA level. Multivariate Logistic regression analysis was used to explore the effect of EDA level on the risk of NAFLD. Results Compared with non-NAFLD group, NAFLD group had much younger mean age, shorter mean duration of T2DM, but significantly higher mean levels of BMI, fasting insulin (FIns), 2-hour postprandial insulin responses (2 hIns), fasting C-peptide (FCP), 2-hour postprandial C-peptide (2 hCP), homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood uric acid (SUA), urea nitrogen (BUN), and EDA level (P<0.05). Pearson correlation analysis showed that the serum EDA level was positively correlated with age, FIns, 2 hIns, HOMA-IR, and AST (r=0.222, 0.186, 0.233, 0.204, 0.189, P<0.05). Multiple linear regression analysis showed that age〔β=1.957, 95%CI (0.412, 3.502), P=0.013〕, WHR〔β=-328.845, 95%CI (-638.903, -18.788), P=0.038〕, 2 hIns〔β=0.523, 95%CI (0.036, 1.011), P=0.036〕 and AST〔β=2.148, 95%CI (0.520, 3.776), P=0.010〕were independently associated with EDA (P<0.05). Multivariate Logistic regression analysis demonstrated that EDA was still associated with NAFLD after adjusting for multiple confounding factors〔OR=1.006, 95%CI (1.002, 1.010), P=0.007〕. Conclusion In T2DM patients with NAFLD, the level of serum EDA was significantly increased, and potentially associated with elevated risk of NAFLD, which suggests that serum EDA level may play a role in the development of NAFLD in T2DM. Our study may provide a theoretical basis for early screening or treatment of NAFLD.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220660.pdfdiabetes mellitus, type 2|non-alcoholic fatty liver disease|ectodysplasin a|insulin resistance|hepatokine|risk factors|correlation study |
| spellingShingle | QIAN Fangfang, CAI Zhensheng, GU Tian, LI Haoxiang, ZHAO Li, YANG Ling, DENG Xia, YUAN Guoyue Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus Zhongguo quanke yixue diabetes mellitus, type 2|non-alcoholic fatty liver disease|ectodysplasin a|insulin resistance|hepatokine|risk factors|correlation study |
| title | Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus |
| title_full | Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus |
| title_short | Relationship between Ectodysplasin A and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus |
| title_sort | relationship between ectodysplasin a and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus, type 2|non-alcoholic fatty liver disease|ectodysplasin a|insulin resistance|hepatokine|risk factors|correlation study |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220660.pdf |
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