Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer
Colon cancer is one of the most common malignancies causing death worldwide. It is well known that the cells of the tumor microenvironment contribute to the progression and prognosis of colon cancer. However, the gene alterations and potential remodeling mechanisms in the tumor microenvironment of c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120302584 |
| _version_ | 1818383885589807104 |
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| author | Ying Wang Yu Wang Caihua Xu Yuhang Liu Zhaohui Huang |
| author_facet | Ying Wang Yu Wang Caihua Xu Yuhang Liu Zhaohui Huang |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Colon cancer is one of the most common malignancies causing death worldwide. It is well known that the cells of the tumor microenvironment contribute to the progression and prognosis of colon cancer. However, the gene alterations and potential remodeling mechanisms in the tumor microenvironment of colon cancer remain largely unknown. In this study, immune scores from the ESTIMATE algorithm were used to discriminate between patients with high or low immune-cell infiltration. There were 42 immune differentially expressed genes (DEGs) of prognostic value identified in this study. Among them, KCNJ5 is a key factor in promoting M2 macrophage recruitment and tumor immune infiltration in colon cancer. These findings may provide novel insights for decoding the complicated interplay between cancer cells and the tumor microenvironment as well as for developing new avenues for therapeutic intervention in colon cancer. |
| first_indexed | 2024-12-14T03:13:29Z |
| format | Article |
| id | doaj.art-ec262bfa3cb444eb9c708992d106e617 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-14T03:13:29Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-ec262bfa3cb444eb9c708992d106e6172022-12-21T23:19:12ZengElsevierMolecular Therapy: Nucleic Acids2162-25312020-12-0122236250Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon CancerYing Wang0Yu Wang1Caihua Xu2Yuhang Liu3Zhaohui Huang4Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China; Corresponding author: Ying Wang, Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.Endoscopy Center, Shanghai East Hospital, Medical College of Tongji University, Shanghai 200120, ChinaDepartment of Oncology, The First Affiliated Hospital of Soochow University, Soochow 215006, Jiangsu, ChinaWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, ChinaWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China; Corresponding author: Zhaohui Huang, Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.Colon cancer is one of the most common malignancies causing death worldwide. It is well known that the cells of the tumor microenvironment contribute to the progression and prognosis of colon cancer. However, the gene alterations and potential remodeling mechanisms in the tumor microenvironment of colon cancer remain largely unknown. In this study, immune scores from the ESTIMATE algorithm were used to discriminate between patients with high or low immune-cell infiltration. There were 42 immune differentially expressed genes (DEGs) of prognostic value identified in this study. Among them, KCNJ5 is a key factor in promoting M2 macrophage recruitment and tumor immune infiltration in colon cancer. These findings may provide novel insights for decoding the complicated interplay between cancer cells and the tumor microenvironment as well as for developing new avenues for therapeutic intervention in colon cancer.http://www.sciencedirect.com/science/article/pii/S2162253120302584KCNJ5tumor microenvironmentM2 macrophagescolon cancerTCGA |
| spellingShingle | Ying Wang Yu Wang Caihua Xu Yuhang Liu Zhaohui Huang Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer Molecular Therapy: Nucleic Acids KCNJ5 tumor microenvironment M2 macrophages colon cancer TCGA |
| title | Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer |
| title_full | Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer |
| title_fullStr | Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer |
| title_full_unstemmed | Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer |
| title_short | Identification of Novel Tumor-Microenvironment-Regulating Factor That Facilitates Tumor Immune Infiltration in Colon Cancer |
| title_sort | identification of novel tumor microenvironment regulating factor that facilitates tumor immune infiltration in colon cancer |
| topic | KCNJ5 tumor microenvironment M2 macrophages colon cancer TCGA |
| url | http://www.sciencedirect.com/science/article/pii/S2162253120302584 |
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