APOBEC3D excludes APOBEC3F from HIV-1 virions by competitive binding of RNA

APOBEC3D excludes APOBEC3F from HIV-1 virions by competitive binding of RNA

The human family of APOBEC3 enzymes are primarily studied as single-stranded DNA deoxycytidine deaminases that act as host restriction factors for a number of viruses and retroelements. The deamination of deoxycytidine to deoxyuridine causes inactivating mutations in target DNA and the nucleic acid...

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Bibliographic Details
Main Authors: Shreoshri Bhattacharjee, Amit Gaba, Linda Chelico
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Virology
Subjects:
restriction factor
HIV
APOBEC3
virion encapsidation
mutagenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2024.1343037/full

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