Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat
Abstract Feline morbillivirus (FeMV) is a recently discovered morbillivirus of the family Paramyxoviridae, which include several highly contagious viruses with zoonotic potential. In this case report we describe the detection of FeMV in archived brain tissue of a 2‐month‐old Bengal cat with nonsuppu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16916 |
| _version_ | 1827310958364590080 |
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| author | Kara L. D. Dawson Nicole Wildi Mauro Cavalli Dennis Rubbenstroth Anna Oevermann Torsten Seuberlich |
| author_facet | Kara L. D. Dawson Nicole Wildi Mauro Cavalli Dennis Rubbenstroth Anna Oevermann Torsten Seuberlich |
| author_sort | Kara L. D. Dawson |
| collection | DOAJ |
| description | Abstract Feline morbillivirus (FeMV) is a recently discovered morbillivirus of the family Paramyxoviridae, which include several highly contagious viruses with zoonotic potential. In this case report we describe the detection of FeMV in archived brain tissue of a 2‐month‐old Bengal cat with nonsuppurative encephalitis from the year 2011 in Switzerland by high‐throughput sequencing (HTS). Our metagenomics approach was able to obtain a full‐length sequence covering the entire FeMV genome. Phylogenetic analysis showed that our FeMV strain clustered within FeMV genotype 1. We were able to detect FeMV RNA by in situ hybridization (ISH) in brain sections with inflammatory lesions and demonstrated its potential neurotropism and association with encephalitis. Our results provide further insight into this recently discovered morbillivirus and encourage further investigations into the pathogenesis and epidemiology of associated diseases in cats and potentially other species. |
| first_indexed | 2024-03-09T00:19:50Z |
| format | Article |
| id | doaj.art-ec2685d73e474d5db4abd22fd8ed2ae3 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-24T20:09:23Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-ec2685d73e474d5db4abd22fd8ed2ae32024-03-23T17:56:17ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-11-013762510251310.1111/jvim.16916Feline morbillivirus infection associated with fatal encephalitis in a Bengal catKara L. D. Dawson0Nicole Wildi1Mauro Cavalli2Dennis Rubbenstroth3Anna Oevermann4Torsten Seuberlich5Division of Neurological Sciences, Vetsuisse Faculty University of Bern Bern SwitzerlandDivision of Neurological Sciences, Vetsuisse Faculty University of Bern Bern SwitzerlandVeterinary Practice Mauro Cavalli Locarno SwitzerlandInstitute for Diagnostic Virology, Friedrich‐Loeffler‐Institute, Federal Research Institute for Animal Health Isle of Riems GermanyDivision of Neurological Sciences, Vetsuisse Faculty University of Bern Bern SwitzerlandDivision of Neurological Sciences, Vetsuisse Faculty University of Bern Bern SwitzerlandAbstract Feline morbillivirus (FeMV) is a recently discovered morbillivirus of the family Paramyxoviridae, which include several highly contagious viruses with zoonotic potential. In this case report we describe the detection of FeMV in archived brain tissue of a 2‐month‐old Bengal cat with nonsuppurative encephalitis from the year 2011 in Switzerland by high‐throughput sequencing (HTS). Our metagenomics approach was able to obtain a full‐length sequence covering the entire FeMV genome. Phylogenetic analysis showed that our FeMV strain clustered within FeMV genotype 1. We were able to detect FeMV RNA by in situ hybridization (ISH) in brain sections with inflammatory lesions and demonstrated its potential neurotropism and association with encephalitis. Our results provide further insight into this recently discovered morbillivirus and encourage further investigations into the pathogenesis and epidemiology of associated diseases in cats and potentially other species.https://doi.org/10.1111/jvim.16916feline encephalitisfeline morbillivirusmetagenomicsneurology |
| spellingShingle | Kara L. D. Dawson Nicole Wildi Mauro Cavalli Dennis Rubbenstroth Anna Oevermann Torsten Seuberlich Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat Journal of Veterinary Internal Medicine feline encephalitis feline morbillivirus metagenomics neurology |
| title | Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat |
| title_full | Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat |
| title_fullStr | Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat |
| title_full_unstemmed | Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat |
| title_short | Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat |
| title_sort | feline morbillivirus infection associated with fatal encephalitis in a bengal cat |
| topic | feline encephalitis feline morbillivirus metagenomics neurology |
| url | https://doi.org/10.1111/jvim.16916 |
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