Tick Salivary Compounds for Targeted Immunomodulatory Therapy
Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.583845/full |
| _version_ | 1818275912513224704 |
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| author | Hajer Aounallah Hajer Aounallah Chaima Bensaoud Youmna M’ghirbi Fernanda Faria Jindr̆ich Chmelar̆ Michail Kotsyfakis Michail Kotsyfakis |
| author_facet | Hajer Aounallah Hajer Aounallah Chaima Bensaoud Youmna M’ghirbi Fernanda Faria Jindr̆ich Chmelar̆ Michail Kotsyfakis Michail Kotsyfakis |
| author_sort | Hajer Aounallah |
| collection | DOAJ |
| description | Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterized in vitro and/or in vivo and present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies. |
| first_indexed | 2024-12-12T22:37:17Z |
| format | Article |
| id | doaj.art-ec2918e06b2e44ce9b2d040a7ccdf3c3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T22:37:17Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec2918e06b2e44ce9b2d040a7ccdf3c32022-12-22T00:09:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.583845583845Tick Salivary Compounds for Targeted Immunomodulatory TherapyHajer Aounallah0Hajer Aounallah1Chaima Bensaoud2Youmna M’ghirbi3Fernanda Faria4Jindr̆ich Chmelar̆5Michail Kotsyfakis6Michail Kotsyfakis7Institut Pasteur de Tunis, LR19IPTX, Service d’Entomologie Médicale, Université de Tunis El Manar, Tunis, TunisiaInnovation and Development Laboratory, Innovation and Development Center, Instituto Butantan, São Paulo, BrazilInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, CzechiaInstitut Pasteur de Tunis, LR19IPTX, Service d’Entomologie Médicale, Université de Tunis El Manar, Tunis, TunisiaInnovation and Development Laboratory, Innovation and Development Center, Instituto Butantan, São Paulo, BrazilDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, České Budějovice, CzechiaInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, CzechiaDepartment of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, České Budějovice, CzechiaImmunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterized in vitro and/or in vivo and present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.https://www.frontiersin.org/article/10.3389/fimmu.2020.583845/fulltick salivasalivary glandshost immunityimmunomodulationdrug discovery |
| spellingShingle | Hajer Aounallah Hajer Aounallah Chaima Bensaoud Youmna M’ghirbi Fernanda Faria Jindr̆ich Chmelar̆ Michail Kotsyfakis Michail Kotsyfakis Tick Salivary Compounds for Targeted Immunomodulatory Therapy Frontiers in Immunology tick saliva salivary glands host immunity immunomodulation drug discovery |
| title | Tick Salivary Compounds for Targeted Immunomodulatory Therapy |
| title_full | Tick Salivary Compounds for Targeted Immunomodulatory Therapy |
| title_fullStr | Tick Salivary Compounds for Targeted Immunomodulatory Therapy |
| title_full_unstemmed | Tick Salivary Compounds for Targeted Immunomodulatory Therapy |
| title_short | Tick Salivary Compounds for Targeted Immunomodulatory Therapy |
| title_sort | tick salivary compounds for targeted immunomodulatory therapy |
| topic | tick saliva salivary glands host immunity immunomodulation drug discovery |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.583845/full |
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