Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15

Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15

Abstract Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription leve...

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Bibliographic Details
Main Authors: Nguyen T. Van, Karen Zhang, Rachel M. Wigmore, Anne I. Kennedy, Carolina R. DaSilva, Jialing Huang, Manju Ambelil, Jose H. Villagomez, Gerald J. O’Connor, Randy S. Longman, Miao Cao, Adam E. Snook, Michael Platten, Gerard Kasenty, Luis J. Sigal, George C. Prendergast, Sangwon V. Kim
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43211-4

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